Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hspd1tm1c(EUCOMM)Hmgu mutation
(0 available);
any
Hspd1 mutation
(46 available)
Tg(Tek-cre)12Flv mutation
(1 available)
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mortality/aging
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• embryos are seen at the expected Mendelian ratio at E10.5 but all embryos between E11.5 and E13.5 are dead and absorbed
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cardiovascular system
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• some vessels exhibit reduced diameters in the head, trunk, and yolk sac at E10.5 but not E9.5
• however, marker analysis shows that endothelial cell differentiation and early development of the yolk sac vascular system appear normal
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embryo
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• E10.5, but not E9.5, embryos are growth retarded
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growth/size/body
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• E10.5, but not E9.5, embryos are growth retarded
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hematopoietic system
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• E10.5 embryos develop severe anemia and are pale
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• E10.5 embryos exhibit an abnormally low number of blood cells in embryos or yolk sacs
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• the numbers of yolk sac erythrocytes are reduced at E9
• however, blood distribution in yolk sacs is similar to controls at E8.5 and the numbers of yolk sac erythrocytes are normal at E8.5
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• cell apoptosis of yolk sac erythrocytes is increased at E9 but not E8.5
• treatment with cyclosporine A decreases erythrocyte cell apoptosis
• mitochondrial membrane potentials of Ter119+ erythrocytes from E8.5 yolk sacs are slightly, but significantly, lower than in controls
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A1cfTg(Myh6-cre/Esr1*)1Jmk mutation
(5 available);
any
A1cf mutation
(39 available)
Hspd1tm1c(EUCOMM)Hmgu mutation
(0 available);
any
Hspd1 mutation
(46 available)
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mortality/aging
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• all mice die within 14 weeks post tamoxifen injection
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cardiovascular system
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• mice show enlarged hearts 11 weeks post tamoxifen injection
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• ratio of ventricular weight to body weight is increased at 11 weeks post tamoxifen injection
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• ventricular wall thinning is seen at 11 weeks post tamoxifen injection
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• ventricular chamber dilation is seen at 11 weeks post tamoxifen injection
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• hearts show severe cardiac fibrosis at 11 weeks post tamoxifen injection
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• increase in number of apoptotic cells is seen in hearts at 11 weeks post tamoxifen injection
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• mice develop dilated cardiomyopathy after tamoxifen injection
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• left ventricle fractional shortening and ejection fraction are slightly decreased at 9 weeks and further decreased at 11 and 13 weeks after tamoxifen injection
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• left ventricle systolic function represented by fractional shortening and ejection fraction is slightly decreased at 9 weeks post tamoxifen injection and further increased at 11 and 13 weeks after tamoxifen injection
• enlarged left ventricle chamber and ventricular wall thinning are seen at 11 and 13 weeks after tamoxifen injection
• left ventricle systolic function further deteriorates at 11 and 13 weeks after tamoxifen injection
• however, ventricular wall thickness and internal dimension of the heart are not altered at 9 weeks post tamoxifen injection
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• mice develop dilated cardiomyopathy and heart failure after tamoxifen injection
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cellular
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• activities of complex I and complex III in mitochondria are impaired at 9 weeks post tamoxifen injection
• activities of all four complexes in mitochondria are impaired at 11 weeks post tamoxifen injection
• cardiomyocytes show reduced mitochondrial potential and increased mitochondrial ROS levels at 9 weeks post tamoxifen injection
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• cardiomyocytes show increased mitochondrial ROS levels at 9 weeks post tamoxifen injection
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muscle
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• mice develop dilated cardiomyopathy after tamoxifen injection
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• left ventricle fractional shortening and ejection fraction are slightly decreased at 9 weeks and further decreased at 11 and 13 weeks after tamoxifen injection
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respiratory system
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• ratio of lung weight to body weight are increased at 11 weeks post tamoxifen injection
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growth/size/body
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• mice show enlarged hearts 11 weeks post tamoxifen injection
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• ratio of lung weight to body weight are increased at 11 weeks post tamoxifen injection
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