Analysis Tools
cardiovascular system
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• at E9.5, half of homozygous embryos show abnormal cardiac development
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hemorrhage
(
J:374598
)
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• some homozygous embryos recovered at E10.5 exhibit abnormal blood deposits, as observed in whole mount
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craniofacial
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• at E9.5, most homozygous embryos appear to have abnormal branchial arches
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• at E9.5, nearly all homozygous embryos exhibit an abnormal head shape
• by E10.5, all embryos that are not dying show abnormal head shape
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embryo
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• at E9.5, nearly all homozygous embryos exhibit incomplete turning
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• most homozygous embryos are developmentally delayed at E8.5
• nearly all are delayed at E9.5; by E10.5, those that are not dying are all delayed
• surprisingly, despite the overall delays, some embryos recovered at E10.5 can exhibit normal histological morphology
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• a minority of homozygous embryos appear abnormal at E8.5
• however, germ layer formation and patterning are normal at E8.5
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• at E9.5, most homozygous embryos appear to have abnormal branchial arches
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• at E7.5 and E8.5, homozygous embryos are smaller than control littermates
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• at E9.5, half of homozygous embryos show abnormal cranial neural tube closure
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• at E9.5, half of homozygous embryos exhibit slight neural tube kinking
• by E10.5, all embryos that are not dying show slight neural tube kinks
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• at E9.5, placentas exhibit multiple labyrinth zone defects
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• at E9.5, the Tfeb+ labyrinth trophoblast layer fails to expand, remaining a thin layer
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• at E9.5, placentas exhibit a diminished Tpbpa+ spongiotrophoblast layer
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• at E9.5, Gcm1+ chorioallantoic branching is severely impaired
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• at E9.5, placentas exhibit an abnormal chorioallantoic interface with a reduction in allantoic mesoderm and limited interface expansion
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growth/size/body
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• at E9.5, nearly all homozygous embryos exhibit an abnormal head shape
• by E10.5, all embryos that are not dying show abnormal head shape
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• most homozygous embryos are developmentally delayed at E8.5
• nearly all are delayed at E9.5; by E10.5, those that are not dying are all delayed
• surprisingly, despite the overall delays, some embryos recovered at E10.5 can exhibit normal histological morphology
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• at E7.5 and E8.5, homozygous embryos are smaller than control littermates
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mortality/aging
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IMPC - JAX
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IMPC - JAX
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• homozygous embryos are present in Mendelian ratios at E7.5 and E8.5, overrepresented at E9.5, in part due to a litter of 8 with 7 mutants, but absent at E12.5; many homozygous embryos are dying at E10.5
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nervous system
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• at E9.5, half of homozygous embryos show abnormal cranial neural tube closure
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• at E9.5, half of homozygous embryos exhibit slight neural tube kinking
• by E10.5, all embryos that are not dying show slight neural tube kinks
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• some homozygous embryos recovered at E10.5 exhibit an abnormal forebrain
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