About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ess2tm1.1Nbioc
targeted mutation 1.1, Nihon University School of Medicine , Division of Biochemistry, Department of Biomedical Sciences
MGI:6376226
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ess2tm1.1Nbioc/Ess2tm1.1Nbioc
Tg(Cd4-cre)1Cwi/0 		involves: C57BL/6N * DBA/2 MGI:7548678


Genotype
MGI:7548678
cn1
Allelic
Composition		 Ess2tm1.1Nbioc/Ess2tm1.1Nbioc
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: C57BL/6N * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ess2tm1.1Nbioc mutation (0 available); any Ess2 mutation (29 available)
Tg(Cd4-cre)1Cwi mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:339504 )
N
• mice exhibit normal double negative to double positive selection in the thymus
decreased CD8-positive, naive alpha-beta T cell number ( J:339504 )
• reduced peripheral naive T cells
abnormal CD4-positive, alpha-beta T cell physiology ( J:339504 )
• CD4+ T cells do not maintain survival in response to IL-7 unlike control cells

hematopoietic system
decreased CD8-positive, naive alpha-beta T cell number ( J:339504 )
• reduced peripheral naive T cells
abnormal CD4-positive, alpha-beta T cell physiology ( J:339504 )
• CD4+ T cells do not maintain survival in response to IL-7 unlike control cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory