Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cadtm1c(KOMP)Wtsi mutation
(0 available);
any
Cad mutation
(73 available)
Tg(Adipoq-rtTA)2Zvw mutation
(1 available)
Tg(tetO-cre)1Jaw mutation
(5 available)
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adipose tissue
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• mice show a moderate size reduction of adipocytes in subcutaneous white adipose tissue (sWAT) when fed a Dox-containing diet
• however, no differences in epididymal white adipose tissue (eWAT) or interscapular brown adipose tissue (BAT) adipocyte size is seen
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growth/size/body
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N |
• mice do not show differences in bodyweight gain from wild-type mice when treated with doxycycline (Dox)
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|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cadtm1c(KOMP)Wtsi mutation
(0 available);
any
Cad mutation
(73 available)
Tg(Adipoq-rtTA)2Zvw mutation
(1 available)
Tg(tetO-cre)1Jaw mutation
(5 available)
Tg(tetO-Xbp1_is)#Pesch mutation
(0 available)
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growth/size/body
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• mice continue to increase their body weight when switched to a doxycycline (Dox)-containing diet, although not at the same extent as wild-type mice thus showing a partial reversal of weight loss
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adipose tissue
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N |
• size of adipocytes is epididymal white adipose tissue (eWAT), subcutaneous white adipose tissue (sWAT), and in interscapular brown adipose tissue (BAT)is normal in Dox-treated mice
• adipose tissue uridine content is not increased and thus rescued in Dox-treated mice compared to Tg(tetO-Xbp1_is)#Pesch/0 Tg(Adipoq-rtTA)2Zvw/0 mice
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homeostasis/metabolism
Analysis Tools