About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Znrf1tm1Lchs
targeted mutation 1, Li-Chung Hsu
MGI:6369072
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Tg(Mx1-cre)1Cgn/0
Znrf1tm1Lchs/Znrf1tm1Lchs 		involves: C57BL/6 MGI:6369077


Genotype
MGI:6369077
cn1
Allelic
Composition		 Tg(Mx1-cre)1Cgn/0
Znrf1tm1Lchs/Znrf1tm1Lchs
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Mx1-cre)1Cgn mutation (10 available)
Znrf1tm1Lchs mutation (0 available); any Znrf1 mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal hematopoietic system physiology ( J:250572 )
• hematopoietic cells display increased resistance to endotoxic and polymicrobial septic shock due to attenuated inflammation

immune system
decreased susceptibility to endotoxin shock ( J:250572 )
• after bacterial lipopolysaccharide (LPS) challenges




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory