About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Plet1em1Yhh
endonuclease-mediated mutation 1, Yina H Huang
MGI:6369063
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Plet1em1Yhh/Plet1em1Yhh Not Specified MGI:6369064


Genotype
MGI:6369064
hm1
Allelic
Composition		 Plet1em1Yhh/Plet1em1Yhh
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plet1em1Yhh mutation (0 available); any Plet1 mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
abnormal tumor susceptibility ( J:251136 )
• substantially reduced tumor numbers in the AOM/DSS colon cancer model

digestive/alimentary system
abnormal intestine physiology ( J:251136 )
• significantly increased gut permiability

homeostasis/metabolism
impaired wound healing ( J:251136 )
• impaired tissue repair of DSS-induced damage in colon epithelium




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory