Plet1^em1Yhh
Endonuclease-mediated Allele Detail

Summary

• Symbol: Plet1^em1Yhh
• Name: placenta expressed transcript 1; endonuclease-mediated mutation 1, Yina H Huang
• MGI ID: MGI:6369063
• Synonyms: Plet1^-
• Gene: Plet1 Location: Chr9:50405825-50416782 bp, + strand Genetic Position: Chr9, 27.71 cM, cytoband B
• Alliance: Plet1^em1Yhh page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-Cas9 technology was used to introduce deletion causing a frameshift mutaion in the coding region. The mutant Plet1 gene expresses a truncated Plet1 protein containing 53AA from plet1 with deletion from 54 aa-end (237aa). (J:251136)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plet1 Mutation: 8 strains or lines available

References

• Original: J:251136 Zepp JA, et al., IL-17A-Induced PLET1 Expression Contributes to Tissue Repair and Colon Tumorigenesis. J Immunol. 2017 Dec 1;199(11):3849-3857
• All: 1 reference(s)