Phenotypes associated with this allele

• Allele Symbol: Pde5a^em1Laj
• Allele Name: endonuclease-mediated mutation 1, Laurinda A Jaffe
• Allele ID: MGI:6368794
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pde5a^em1Laj/Pde5a^em1Laj	involves: C57BL/6J	MGI:6368804

Genotype
MGI:6368804

hm1

• Allelic Composition: Pde5a^em1Laj/Pde5a^em1Laj
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:258770 )

• mice are viable, fertile and show no obvious morphological or behavioral abnormalities

• despite a reduction of PDE5A activity and total cGMP-hydrolytic activity in response to luteinizing hormone, ovarian follicles treated with luteinizing hormone undergo spontaneous nuclear envelope breakdown as in wild-type follicles, indicating that timing of oocyte meiotic resumption is not affected