All Phenotypes Bcap31<tm1.1Bwang> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Bcap31^tm1.1Bwang/Bcap31^tm1.1Bwang Lyz2^tm1(cre)Ifo/Lyz2⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:6714084
cn2	Bcap31^tm1.1Bwang/Bcap31^tm1.1Bwang Tg(Lck-cre)548Jxm/0	involves: C57BL/6 * CBA	MGI:6719029

Allelic Composition	Bcap31^tm1.1Bwang/Bcap31^tm1.1Bwang Lyz2^tm1(cre)Ifo/Lyz2⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcap31^tm1.1Bwang mutation (0 available); any Bcap31 mutation (8 available)
Lyz2^tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased microglial cell activation ( J:292505 )

• increased number of Iba1-labeled activated microglia in the hippocampal CA1 and dentate gurus (DG) areas after intracerebroventricular (i.c.v.) LPS administration

increased interleukin-1 beta secretion ( J:292505 )

• increased Il1b mRNA levels in the hippocampus after i.c.v. LPS administration

• increased IL-1beta protein levels in primary microglial cells after LPS administration for 24 h

increased tumor necrosis factor secretion ( J:292505 )

• increased Tnf mRNA levels in the hippocampus after i.c.v. LPS administration

• increased TNF protein levels in primary microglial cells after LPS administration for 24 h

increased inflammatory response ( J:292505 )

• increased mRNA expression of proinflammatory factors (Tnf, Il1b, Nos2 and Ptgs2) in the hippocampus after i.c.v. LPS administration

nervous system

increased microglial cell activation ( J:292505 )

• increased number of Iba1-labeled activated microglia in the hippocampal CA1 and dentate gurus (DG) areas after intracerebroventricular (i.c.v.) LPS administration

decreased neuron number ( J:292505 )

• decreased number of NeuN-labeled intact neurons in the hippocampal CA1 and dentate gurus (DG) areas after i.c.v. LPS administration

homeostasis/metabolism

abnormal enzyme/coenzyme level ( J:292505 )

• increased Nos2 (nitric oxide synthase 2, inducible; aka iNOS) and Ptgs2 (prostaglandin-endoperoxide synthase 2; aka cyclooxygenase-2, Cox2) mRNA levels in the hippocampus following i.c.v. LPS administration

behavior/neurological

behavior/neurological phenotype ( J:292505 )

N	• no alterations in spontaneous locomotor activity (total moving distance) in the open field test 7 days after i.c.v. LPS administration at 2 months of age

abnormal spatial reference memory ( J:292505 )

• mice exhibit severe deficits in spatial memory formation after i.c.v. LPS administration

• in the Morris water maze test, the escape latency on training day 3, 4 and 5 is longer in LPS-treated mice relative to that in LPS-treated controls; in the probe test, LPS-treated mice show a reduced number of platform-site crossings, travel a shorter distance and spend less time in the target quadrant than LPS-treated controls

• in the Y-maze test, LPS-treated mice show a reduced number of alterations but no change in the total number of arm entries relative to LPS-treated controls

hematopoietic system

increased microglial cell activation ( J:292505 )

• increased number of Iba1-labeled activated microglia in the hippocampal CA1 and dentate gurus (DG) areas after intracerebroventricular (i.c.v.) LPS administration

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased thymocyte apoptosis ( J:274469 )

• accelerated apoptosis in freshly isolated thymocytes after tunicamycin treatment

small thymus ( J:274469 )

• decreased thymus size in young adult (3-, 5- or 8-week-old) and older mice (6-month-old)

decreased thymus weight ( J:274469 )

• decreased thymus weight in young adult and older mice

thymus hypoplasia ( J:274469 )

decreased thymocyte number ( J:274469 )

• reduced total thymocyte number in young adult and older mice

• however, development of double-negative (DN) thymocytes and CD4+ and CD8+ single-positive (SP) thymocytes is normal

• no significant change in DN1-4 thymic subsets

decreased CD8-positive, naive alpha-beta T cell number ( J:274469 )

• decreased % of naive (CD44^lowCD62L^hi) in CD4+ and CD8+ T cells in the spleen and lymph nodes of young adult (8-wk-old) and older mice (6-mo-old)

increased effector memory T-helper cell number ( J:274469 )

• increased % of effector/memory T cells (CD44^hiCD62L^lo) in CD4+ and CD8+ T cells in the spleen and lymph nodes of young adult (8-wk-old) and older mice (6-mo-old)

decreased single-positive T cell number ( J:274469 )

• decreased percentage of CD4+ and CD8+ single positive (SP) mature T lymphocytes in the spleen and lymph nodes of young adult (3-, 5- or 8-week-old) and older mice (6-month-old)

• decreased percentage of CD4+ and CD8+ T cells in peripheral blood

• however, expression of class I MHC molecules on CD4+ and CD8+ SP splenocytes is normal

abnormal T cell activation ( J:274469 )

• marked reduction in IL-2 and IFN-gamma production following stimulation of total splenocytes with anti-CD3 plus anti-CD28

decreased T cell proliferation ( J:274469 )

• reduced T cell proliferation following stimulation of total splenocytes with anti-CD3 plus anti-CD28

decreased interferon-gamma secretion ( J:274469 )

• marked reduction in IFN-gamma production following stimulation of total splenocytes with anti-CD3 plus anti-CD28; also detected at the mRNA level

decreased interleukin-2 secretion ( J:274469 )

• marked reduction in IL-2 production following stimulation of total splenocytes with anti-CD3 plus anti-CD28; also detected at the mRNA level

hematopoietic system

increased thymocyte apoptosis ( J:274469 )

• accelerated apoptosis in freshly isolated thymocytes after tunicamycin treatment

small thymus ( J:274469 )

• decreased thymus size in young adult (3-, 5- or 8-week-old) and older mice (6-month-old)

decreased thymus weight ( J:274469 )

• decreased thymus weight in young adult and older mice

thymus hypoplasia ( J:274469 )

decreased thymocyte number ( J:274469 )

• reduced total thymocyte number in young adult and older mice

• however, development of double-negative (DN) thymocytes and CD4+ and CD8+ single-positive (SP) thymocytes is normal

• no significant change in DN1-4 thymic subsets

decreased CD8-positive, naive alpha-beta T cell number ( J:274469 )

• decreased % of naive (CD44^lowCD62L^hi) in CD4+ and CD8+ T cells in the spleen and lymph nodes of young adult (8-wk-old) and older mice (6-mo-old)

increased effector memory T-helper cell number ( J:274469 )

• increased % of effector/memory T cells (CD44^hiCD62L^lo) in CD4+ and CD8+ T cells in the spleen and lymph nodes of young adult (8-wk-old) and older mice (6-mo-old)

decreased single-positive T cell number ( J:274469 )

• decreased percentage of CD4+ and CD8+ single positive (SP) mature T lymphocytes in the spleen and lymph nodes of young adult (3-, 5- or 8-week-old) and older mice (6-month-old)

• decreased percentage of CD4+ and CD8+ T cells in peripheral blood

• however, expression of class I MHC molecules on CD4+ and CD8+ SP splenocytes is normal

abnormal T cell activation ( J:274469 )

• marked reduction in IL-2 and IFN-gamma production following stimulation of total splenocytes with anti-CD3 plus anti-CD28

decreased T cell proliferation ( J:274469 )

• reduced T cell proliferation following stimulation of total splenocytes with anti-CD3 plus anti-CD28

cellular

increased thymocyte apoptosis ( J:274469 )

• accelerated apoptosis in freshly isolated thymocytes after tunicamycin treatment

decreased T cell proliferation ( J:274469 )

• reduced T cell proliferation following stimulation of total splenocytes with anti-CD3 plus anti-CD28

endocrine/exocrine glands

increased thymocyte apoptosis ( J:274469 )

• accelerated apoptosis in freshly isolated thymocytes after tunicamycin treatment

small thymus ( J:274469 )

• decreased thymus size in young adult (3-, 5- or 8-week-old) and older mice (6-month-old)

decreased thymus weight ( J:274469 )

• decreased thymus weight in young adult and older mice

thymus hypoplasia ( J:274469 )

decreased thymocyte number ( J:274469 )

• reduced total thymocyte number in young adult and older mice

• however, development of double-negative (DN) thymocytes and CD4+ and CD8+ single-positive (SP) thymocytes is normal

• no significant change in DN1-4 thymic subsets

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23