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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Irf8em1Kmm
endonuclease-mediated mutation 1, Kenneth Murphy
MGI:6368518
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Irf8em1Kmm/Irf8em1Kmm
Rr253em6Kmm/Rr253em6Kmm 		C57BL/6J-Irf8em1Kmm Rr253em6Kmm MGI:7448526


Genotype
MGI:7448526
cx1
Allelic
Composition		 Irf8em1Kmm/Irf8em1Kmm
Rr253em6Kmm/Rr253em6Kmm
Genetic
Background		 C57BL/6J-Irf8em1Kmm Rr253em6Kmm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf8em1Kmm mutation (1 available); any Irf8 mutation (32 available)
Rr253em6Kmm mutation (1 available); any Rr253 mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:334296 )
N
• normal granuloma formation in small intestine, egg burden and T-helper 2 cell response after infection with Heligmosomoides polygyrus (H. polygyrus)
• normal splenic cDC2 numbers
decreased granulocyte monocyte progenitor cell number ( J:334296 )
• reduced number of specified monocyte progenitor cells (cMoPs) in bone marrow
decreased dendritic cell number ( J:334296 )
• bone marrow pre-cDC2s virtually absent
• splenic cDC1s virtually absent
increased dendritic cell number ( J:334296 )
• increase of bone marrow pre-cDC1 numbers

immune system
immune system phenotype ( J:334296 )
N
• normal granuloma formation in small intestine, egg burden and T-helper 2 cell response after infection with Heligmosomoides polygyrus (H. polygyrus)
• normal splenic cDC2 numbers
decreased dendritic cell number ( J:334296 )
• bone marrow pre-cDC2s virtually absent
• splenic cDC1s virtually absent
increased dendritic cell number ( J:334296 )
• increase of bone marrow pre-cDC1 numbers




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory