All Phenotypes Mirc33<tm1.1Wtsi> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mirc33^tm1.1Wtsi/Mirc33^tm1.1Wtsi	C57BL/6N-Mirc33^tm1.1Wtsi	MGI:6367598
cx2	Mirc29^tm1.1Wtsi/Mirc29^tm1.1Wtsi Mirc33^tm1.1Wtsi/Mirc33^tm1.1Wtsi	C57BL/6N-Mirc29^tm1.1Wtsi Mirc33^tm1.1Wtsi	MGI:6367622
cx3	Mirc33^tm1.1Wtsi/Mirc33^tm1.1Wtsi Ppargc1a^tm1Brsp/Ppargc1a⁺	involves: 129S4/SvJae * C57BL/6N	MGI:6367623

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:267719 )

• premature death, with a median lifespan of 30 weeks compared to 123 weeks in controls

growth/size/body

decreased body weight ( J:267719 )

• mice develop body weight reduction after the 4th month of life

adipose tissue

decreased brown adipose tissue amount ( J:267719 )

• mice show a reduction in brown adipose tissue after the 4th month of life

decreased white adipose tissue amount ( J:267719 )

• mice show a reduction in white adipose tissue after the 4th month of life

decreased fat cell size ( J:267719 )

• mice exhibit smaller adipocytes

behavior/neurological

ataxia ( J:267719 )

• mice develop severe ataxia

hunched posture ( J:267719 )

• mice exhibit abnormal posture characterized by a hunched position

cardiovascular system

abnormal pulmonary artery morphology ( J:267719 )

• mice develop hypertrophy of small pulmonary arteries with thickening of the tunica media

abnormal aorta morphology ( J:267719 )

• aortas exhibit higher amount of elastic fibers indicating aortic fibrosis

abnormal aorta tunica adventitia morphology ( J:267719 )

• fibrotic accumulation in the tunica adventitia

increased aorta wall thickness ( J:267719 )

• medial thickening in the vessel wall of the aorta

abnormal heart morphology ( J:267719 )

• necrotic areas with collagen accumulation are seen in hearts

hypertension ( J:267719 )

• mice develop systemic hypertension, showing higher levels of systemic blood pressure

cellular

increased mitochondrial DNA content ( J:267719 )

• increase in cardiac mitochondrial DNA

decreased mitochondrial size ( J:267719 )

• cardiac mitochondrial size is smaller, with an accumulation of smaller rounded mitochondria in cardiomyocytes

increased mitochondrial number ( J:267719 )

• increase in the number of mitochondria in hearts

homeostasis/metabolism

decreased circulating creatinine level ( J:267719 )

• serum creatinine level is lower

• however, the kidneys do not show any morphological alteration

increased susceptibility to injury ( J:267719 )

• 3 month old mice administered angiotensin II develop more large fibrotic lesions than controls

• 3 month old mice show higher susceptibility to angiotensin II-induced cardiac heart failure, as 40% of mice die during treatment

renal/urinary system

distended urinary bladder ( J:267719 )

• severe bladder distension

abnormal urothelium morphology ( J:267719 )

• the growing pressure inside the bladder is accompanied by urothelium and muscular layer atrophy

ischuria ( J:267719 )

• urinary retention

reproductive system

infertility ( J:267719 )

skeleton

kyphosis ( J:267719 )

• mice develop thoracic kyphosis

vision/eye

ocular hypertension ( J:267719 )

blindness ( J:267719 )

• eye degeneration and blindness

Allelic Composition	Mirc29^tm1.1Wtsi/Mirc29^tm1.1Wtsi Mirc33^tm1.1Wtsi/Mirc33^tm1.1Wtsi
Genetic Background	C57BL/6N-Mirc29^tm1.1Wtsi Mirc33^tm1.1Wtsi

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc29^tm1.1Wtsi mutation (0 available); any Mirc29 mutation (1 available)
Mirc33^tm1.1Wtsi mutation (0 available); any Mirc33 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:267719 )

• life span is reduced to a median of 23 days

growth/size/body

decreased body weight ( J:267719 )

• mice show reduced body weight few days after birth

postnatal growth retardation ( J:267719 )

• striking growth retardation

cardiovascular system

abnormal heart morphology ( J:267719 )

• necrotic areas with collagen accumulation are seen in hearts

homeostasis/metabolism

increased fasting circulating glucose level ( J:267719 )

• fasted mice exhibit hyperglycemia

decreased circulating glucose level ( J:267719 )

• reduction in serum glucose concentration in nonfasted mice

decreased circulating insulin level ( J:267719 )

Allelic Composition	Mirc33^tm1.1Wtsi/Mirc33^tm1.1Wtsi Ppargc1a^tm1Brsp/Ppargc1a⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc33^tm1.1Wtsi mutation (0 available); any Mirc33 mutation (0 available)
Ppargc1a^tm1Brsp mutation (1 available); any Ppargc1a mutation (47 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:267719 )

• mice exhibit a life span extension compared with single Mirc33^tm1.1Wtsi homozygotes, with a median of 39.5 weeks compared to 30 weeks, but reduced survival compared to wild-type mice

cellular

decreased mitochondrial size ( J:267719 )

• cardiac mitochondrial size is smaller

• however, cardiac mitochondrial DNA levels and mitochondrial numbers are restored to wild-type levels

cardiovascular system

cardiovascular system phenotype ( J:267719 )

N	• mice show a reduction in systemic blood pressure compared to single Mirc33^tm1.1Wtsi homozygotes

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