Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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neoplasm
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• induced by azoxymethane/dextran sodium sulfate
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homeostasis/metabolism
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata6osem1Zfa mutation
(0 available);
any
Gata6os mutation
(0 available)
Gt(ROSA)26Sortm1Sor mutation
(8 available);
any
Gt(ROSA)26Sor mutation
(944 available)
Lgr5tm1(cre/ERT2)Cle mutation
(1 available);
any
Lgr5 mutation
(57 available)
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digestive/alimentary system
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• impaired intestinal epithelial renewal in tamoxifen treated mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata6osem1Zfa mutation
(0 available);
any
Gata6os mutation
(0 available)
Lgr5tm1(cre/ERT2)Cle mutation
(1 available);
any
Lgr5 mutation
(57 available)
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digestive/alimentary system
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• reduced intestinal stem cells with impaired organoid formation capacity
• however, overexpression of Ehf rescues this phenotype
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• short with fewer cells than in wild-type mice
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• short with fewer cells than in wild-type mice
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• impaired intestinal epithelium regeneration after radiation injury compared with wild-type mice
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endocrine/exocrine glands
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• short with fewer cells than in wild-type mice
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homeostasis/metabolism
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation
(12 available);
any
Apc mutation
(154 available)
Gata6osem1Zfa mutation
(0 available);
any
Gata6os mutation
(0 available)
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mortality/aging
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• compared with ApcMin heterozygotes
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neoplasm
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• fewer adenoma and increased survival compared with ApcMin heterozygotes
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digestive/alimentary system
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• fewer adenoma and increased survival compared with ApcMin heterozygotes
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