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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pianpem1Bet
endonuclease-mediated mutation 1, Bernhard Bettler
MGI:6363553
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pianpem1Bet/Pianpem1Bet involves: C57BL/6 MGI:6364112
hm2
 		Pianpem1Bet/Pianpem1Bet Not Specified MGI:6364111


Genotype
MGI:6364112
hm1
Allelic
Composition		 Pianpem1Bet/Pianpem1Bet
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pianpem1Bet mutation (0 available); any Pianp mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:276486 )
N
• normal response to baclofen-induced reduction of evoked EPSC amplitude




Genotype
MGI:6364111
hm2
Allelic
Composition		 Pianpem1Bet/Pianpem1Bet
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pianpem1Bet mutation (0 available); any Pianp mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal excitatory postsynaptic currents ( J:279537 )
• reduced mEPSC frequency inhibition in baclofen-treated mice
• however, baseline mEPSC frequency and amplitude are normal
decreased prepulse inhibition ( J:279537 )
• only at the prepulse levels 76 dB and 80 dB
abnormal paired-pulse facilitation ( J:279537 )
• baclofen-treated mice fail to exhibit an increase in paired-pulse ratio unlike wild-type mice

homeostasis/metabolism
abnormal glutamic acid level ( J:279537 )
• reduced baclofen-mediated inhibition of glutamate release with 40 Hz train stimulation




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory