All Phenotypes Pianp<em1Bet> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pianp^em1Bet
endonuclease-mediated mutation 1, Bernhard Bettler
MGI:6363553

Summary

2 genotypes

Allelic Composition	Pianp^em1Bet/Pianp^em1Bet
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pianp^em1Bet mutation (0 available); any Pianp mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:276486 )

N	• normal response to baclofen-induced reduction of evoked EPSC amplitude

Allelic Composition	Pianp^em1Bet/Pianp^em1Bet
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pianp^em1Bet mutation (0 available); any Pianp mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

• reduced mEPSC frequency inhibition in baclofen-treated mice

• however, baseline mEPSC frequency and amplitude are normal

decreased prepulse inhibition ( J:279537 )

• only at the prepulse levels 76 dB and 80 dB

• baclofen-treated mice fail to exhibit an increase in paired-pulse ratio unlike wild-type mice

homeostasis/metabolism

abnormal glutamic acid level ( J:279537 )

• reduced baclofen-mediated inhibition of glutamate release with 40 Hz train stimulation

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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