Pianp^em1Bet
Endonuclease-mediated Allele Detail

Summary

• Symbol: Pianp^em1Bet
• Name: PILR alpha associated neural protein; endonuclease-mediated mutation 1, Bernhard Bettler
• MGI ID: MGI:6363553
• Gene: Pianp Location: Chr6:124973683-124980059 bp, + strand Genetic Position: Chr6, 59.17 cM
• Alliance: Pianp^em1Bet page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR targeting altered the targeting sequence 5'-GACCCCACACTATAGCCCAAGGG-3' to 5'-GACCCCACACTATAGGTGTGAGATGGG-3' and resulted in a frame shift after P97 and premature termination of translation. (J:276486)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pianp Mutation: 13 strains or lines available

References

• Original: J:276486 Dinamarca MC, et al., Complex formation of APP with GABAB receptors links axonal trafficking to amyloidogenic processing. Nat Commun. 2019 Mar 22;10(1):1331
• All: 2 reference(s)