All Phenotypes Usp11<tm1Tac> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Usp11^tm1Tac/Usp11^tm1Tac	involves: 129 * C57BL/6	MGI:6363165
cx2	Tg(TRAMP)8247Ng/0 Usp11^tm1Tac/Y	involves: 129 * C57BL/6	MGI:6363166
ot3	Usp11^tm1Tac/Y	involves: 129 * C57BL/6	MGI:6363164

Allelic Composition	Usp11^tm1Tac/Usp11^tm1Tac
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Usp11^tm1Tac mutation (0 available); any Usp11 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:270214 )

• viable

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased prostate gland adenocarcinoma incidence ( J:270214 )

• tumors progress to a highly penetrant invasive prostatic adenocarcinoma unlike in age-matched transgenic mice wild-type for Usp11

increased prostate intraepithelial neoplasia incidence ( J:270214 )

• significantly higher rate of high grade prostatic intraepithelial neoplasia compared to transgenic mice wild-type for Usp11

increased metastatic potential ( J:270214 )

• at 20 weeks of age tumor masses show severe malignant progression unlike in age-matched transgenic mice wild-type for Usp11

• prostatic tumor nodules metastasize to lymph nodes at a higher rate compared to age-matched transgenic mice wild-type for Usp11

increased tumor growth/size ( J:270214 )

• tumor masses are larger at 20 weeks of age compared to transgenic mice wild-type for Usp11

endocrine/exocrine glands

increased prostate gland adenocarcinoma incidence ( J:270214 )

• tumors progress to a highly penetrant invasive prostatic adenocarcinoma unlike in age-matched transgenic mice wild-type for Usp11

increased prostate intraepithelial neoplasia incidence ( J:270214 )

• significantly higher rate of high grade prostatic intraepithelial neoplasia compared to transgenic mice wild-type for Usp11

reproductive system

increased prostate gland adenocarcinoma incidence ( J:270214 )

• tumors progress to a highly penetrant invasive prostatic adenocarcinoma unlike in age-matched transgenic mice wild-type for Usp11

increased prostate intraepithelial neoplasia incidence ( J:270214 )

• significantly higher rate of high grade prostatic intraepithelial neoplasia compared to transgenic mice wild-type for Usp11

Allelic Composition	Usp11^tm1Tac/Y
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Usp11^tm1Tac mutation (0 available); any Usp11 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal fibroblast physiology ( J:270214 )

• in a wounding assay primary MEFs show more rapid wound closure compared to wild-type controls

• increase in the rates of glucose uptake, lactate production, and glutamine consumption in primary MEFs compared to wild-type controls

increased fibroblast proliferation ( J:270214 )

• primary MEFs show a higher rate of growth compared to wild-type controls

endocrine/exocrine glands

prostate gland epithelial hyperplasia ( J:270214 )

• at 11 weeks of age

enlarged prostate gland ( J:270214 )

• enlarged lobes at 11 weeks of age

reproductive system

prostate gland epithelial hyperplasia ( J:270214 )

• at 11 weeks of age

enlarged prostate gland ( J:270214 )

• enlarged lobes at 11 weeks of age

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23