All Phenotypes Bcl7b<tm1Ban> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Bcl7b^tm1Ban
targeted mutation 1, Daniele Bano
MGI:6361909

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Bcl7a^tm1Ban/Bcl7a^tm1Ban Bcl7b^tm1Ban/Bcl7b^tm1Ban Tg(Syn1-cre)671Jxm/0	B6.Cg-Bcl7a^tm1Ban Bcl7b^tm1Ban Tg(Syn1-cre)671Jxm	MGI:6361930

Allelic Composition	Bcl7a^tm1Ban/Bcl7a^tm1Ban Bcl7b^tm1Ban/Bcl7b^tm1Ban Tg(Syn1-cre)671Jxm/0
Genetic Background	B6.Cg-Bcl7a^tm1Ban Bcl7b^tm1Ban Tg(Syn1-cre)671Jxm

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl7a^tm1Ban mutation (0 available); any Bcl7a mutation (29 available)
Bcl7b^tm1Ban mutation (0 available); any Bcl7b mutation (75 available)
Tg(Syn1-cre)671Jxm mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:279171 )

N	• no defects in spatial learning are detected

impaired coordination ( J:279171 )

• on a rotarod

impaired swimming ( J:279171 )

• decrease in swim speeding and increased floating behavior

nervous system

abnormal Purkinje cell dendrite morphology ( J:279171 )

• complexity of the arbor is significantly reduced, but is similar to mutant mice wild-type for Bcl7b

• however, the number and alignment of Purkinje neurons is similar to controls

growth/size/body

decreased body weight ( J:279171 )

• mild reduction

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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