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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bcl7atm1Ban
targeted mutation 1, Daniele Bano
MGI:6361906
Summary 2 genotypes


Genotype
MGI:6361930
cn1
Allelic
Composition		 Bcl7atm1Ban/Bcl7atm1Ban
Bcl7btm1Ban/Bcl7btm1Ban
Tg(Syn1-cre)671Jxm/0
Genetic
Background		 B6.Cg-Bcl7atm1Ban Bcl7btm1Ban Tg(Syn1-cre)671Jxm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl7atm1Ban mutation (0 available); any Bcl7a mutation (27 available)
Bcl7btm1Ban mutation (0 available); any Bcl7b mutation (74 available)
Tg(Syn1-cre)671Jxm mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:279171 )
N
• no defects in spatial learning are detected
impaired coordination ( J:279171 )
• on a rotarod
impaired swimming ( J:279171 )
• decrease in swim speeding and increased floating behavior

nervous system
abnormal Purkinje cell dendrite morphology ( J:279171 )
• complexity of the arbor is significantly reduced, but is similar to mutant mice wild-type for Bcl7b
• however, the number and alignment of Purkinje neurons is similar to controls

growth/size/body
decreased body weight ( J:279171 )
• mild reduction




Genotype
MGI:6361928
cn2
Allelic
Composition		 Bcl7atm1Ban/Bcl7atm1Ban
Tg(Syn1-cre)671Jxm/0
Genetic
Background		 B6.Cg-Bcl7atm1Ban Tg(Syn1-cre)671Jxm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl7atm1Ban mutation (0 available); any Bcl7a mutation (27 available)
Tg(Syn1-cre)671Jxm mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:279171 )
N
• no defects in spatial learning are detected in a Morris water maze
impaired coordination ( J:279171 )
• shorter latency to fall off a rotarod and fail to improve performance with training
impaired swimming ( J:279171 )
• decrease in swim speeding and slightly increased floating behavior
abnormal gait ( J:279171 )
• slightly abnormal with increased front paw stand duration and stride length and reduced paw overlap

nervous system
abnormal Purkinje cell dendrite morphology ( J:279171 )
• complexity of the arbor is significantly reduced
• however, the number and alignment of Purkinje neurons is similar to controls

growth/size/body
decreased body weight ( J:279171 )
• decrease in body weight is seen at 6 months of age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory