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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Peak1tm1.2Itl
targeted mutation 1.2, inGenious Targeting Laboratory
MGI:6361447
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Peak1tm1.2Itl/Peak1tm1.2Itl involves: C57BL/6NTac * FVB/N MGI:6361457
ht2
Peak1tm1.2Itl/Peak1+ involves: C57BL/6NTac * FVB/N MGI:6361458


Genotype
MGI:6361457
hm1
Allelic
Composition
Peak1tm1.2Itl/Peak1tm1.2Itl
Genetic
Background
involves: C57BL/6NTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Peak1tm1.2Itl mutation (0 available); any Peak1 mutation (70 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• reduced outgrowth of superficial vessel plexus with reduced numbers of branch points at P7
• however, adult retina vascular plexus are normal
• reduced microvascular density in injected E0771 breast cancer cells infected with a VEFGA-expressing adenovirus
• with reduced de novo cumulative vessel formation and reduced number of new vessel sprouts aorta treated with VEGFA

neoplasm
• reduced microvascular density in injected E0771 breast cancer cells infected with a VEFGA-expressing adenovirus

hematopoietic system
N
• mice exhibit normal complete blood counts

craniofacial
• increased incidence compared to in C57BL/6J mice

growth/size/body
• increased incidence compared to in C57BL/6J mice

skeleton
• increased incidence compared to in C57BL/6J mice

vision/eye
• reduced outgrowth of superficial vessel plexus with reduced numbers of branch points at P7
• however, adult retina vascular plexus are normal




Genotype
MGI:6361458
ht2
Allelic
Composition
Peak1tm1.2Itl/Peak1+
Genetic
Background
involves: C57BL/6NTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Peak1tm1.2Itl mutation (0 available); any Peak1 mutation (70 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• with reduced de novo cumulative vessel formation and reduced number of new vessel sprouts aorta treated with VEGFA





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory