Phenotypes associated with this allele

• Allele Symbol: Aatf^em1(IMPC)J
• Allele Name: endonuclease-mediated mutation 1, Jackson
• Allele ID: MGI:6361005
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Aatf^em1(IMPC)J/Aatf^em1(IMPC)J	C57BL/6NJ-Aatf^em1(IMPC)J/Mmjax	MGI:6731236
ht2	Aatf^em1(IMPC)J/Aatf^+	C57BL/6NJ-Aatf^em1(IMPC)J/Mmjax	MGI:6696642

Genotype
MGI:6731236

hm1

• Allelic Composition: Aatf^em1(IMPC)J/Aatf^em1(IMPC)J
• Genetic Background: C57BL/6NJ-Aatf^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Aatf

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Aatf^em1(IMPC)J/Aatf^em1(IMPC)J mice exhibit embryonic lethality by E3.5. Morula-like embryos fail to hatch from the zona pellucida in vitro.

embryo

failure of blastocyst to hatch from the zona pellucida ( J:279207 )

• in vitro, morula-like embryos fail to hatch from the zona pellucida after 3 days in culture

embryonic growth arrest ( J:279207 )

• homozygous embryos recovered at E3.5 appear dead

• in vitro, morula-like embryos do not develop further

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

embryonic lethality before implantation, complete penetrance ( J:279207 )

• homozygous embryos are recovered at E3.5 but appear dead; no homozygous embryos are recovered at E7.5

• however, excess resorption sites suggest that embryos elicit a decidual response in vivo

reproductive system

failure of embryo implantation ( J:279207 )

• in vitro, morula-like embryos fail to hatch and form outgrowths after 3 days in culture

Genotype
MGI:6696642

ht2

• Allelic Composition: Aatf^em1(IMPC)J/Aatf⁺
• Genetic Background: C57BL/6NJ-Aatf^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Aatf

behavior/neurological

hyperactivity ( J:211773 )

♀

IMPC - JAX