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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Vgll4tm1c(EUCOMM)Hmgu
targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
MGI:6360734
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Vgll4tm1b(EUCOMM)Hmgu/Vgll4tm1c(EUCOMM)Hmgu
Yap1tm1.1Fcam/Yap1+
Tg(Tek-cre)1Ywa/0 		involves: 129S4/SvJae * C57BL/6N * CBA * SJL MGI:6360911
cn2
 		Vgll4tm1b(EUCOMM)Hmgu/Vgll4tm1c(EUCOMM)Hmgu
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+
Tg(Tek-cre)1Ywa/0 		involves: 129S6/SvEvTac * C57BL/6NCrl * CBA * SJL MGI:6360909
cn3
 		Vgll4tm1b(EUCOMM)Hmgu/Vgll4tm1c(EUCOMM)Hmgu
H2az2Tg(Wnt1-cre)11Rth/H2az2+ 		involves: C57BL/6J * C57BL/6N * CBA/J * SJL MGI:6360913
cn4
 		Vgll4tm1b(EUCOMM)Hmgu/Vgll4tm1c(EUCOMM)Hmgu
Tg(Tek-cre)1Ywa/0 		involves: C57BL/6N * CBA * SJL MGI:6360907


Genotype
MGI:6360911
cn1
Allelic
Composition		 Vgll4tm1b(EUCOMM)Hmgu/Vgll4tm1c(EUCOMM)Hmgu
Yap1tm1.1Fcam/Yap1+
Tg(Tek-cre)1Ywa/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6N * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Tek-cre)1Ywa mutation (6 available)
Vgll4tm1b(EUCOMM)Hmgu mutation (1 available); any Vgll4 mutation (24 available)
Vgll4tm1c(EUCOMM)Hmgu mutation (0 available); any Vgll4 mutation (24 available)
Yap1tm1.1Fcam mutation (0 available); any Yap1 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:273437 )
N
• hearts are normal morphology and function with normal valve thickness and cardiomyocyte proliferation and apoptosis rates




Genotype
MGI:6360909
cn2
Allelic
Composition		 Vgll4tm1b(EUCOMM)Hmgu/Vgll4tm1c(EUCOMM)Hmgu
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+
Tg(Tek-cre)1Ywa/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6NCrl * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze mutation (5 available); any Gt(ROSA)26Sor mutation (944 available)
Tg(Tek-cre)1Ywa mutation (6 available)
Vgll4tm1b(EUCOMM)Hmgu mutation (1 available); any Vgll4 mutation (24 available)
Vgll4tm1c(EUCOMM)Hmgu mutation (0 available); any Vgll4 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal heart development ( J:273437 )
• non-cell autonomous, enhanced proliferation of endothelial-derived valvar interstitial cells leading to valve thickening




Genotype
MGI:6360913
cn3
Allelic
Composition		 Vgll4tm1b(EUCOMM)Hmgu/Vgll4tm1c(EUCOMM)Hmgu
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: C57BL/6J * C57BL/6N * CBA/J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Vgll4tm1b(EUCOMM)Hmgu mutation (1 available); any Vgll4 mutation (24 available)
Vgll4tm1c(EUCOMM)Hmgu mutation (0 available); any Vgll4 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:273437 )
N
• neonatal and adult mice exhibit normal valves




Genotype
MGI:6360907
cn4
Allelic
Composition		 Vgll4tm1b(EUCOMM)Hmgu/Vgll4tm1c(EUCOMM)Hmgu
Tg(Tek-cre)1Ywa/0
Genetic
Background		 involves: C57BL/6N * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Tek-cre)1Ywa mutation (6 available)
Vgll4tm1b(EUCOMM)Hmgu mutation (1 available); any Vgll4 mutation (24 available)
Vgll4tm1c(EUCOMM)Hmgu mutation (0 available); any Vgll4 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:273437 )
N
• neonatal mice exhibit normal capillary vessel distribution and endocardium
increased myocardial fiber size ( J:273437 )
• increased cross sectional area
abnormal heart development ( J:273437 )
• prolonged cell proliferation and reduced apoptosis of endothelial-derived valvar interstitial cells
increased heart weight ( J:273437 )
• relative to body weight
cardiac hypertrophy ( J:273437 )
• severe at 36 weeks of age
thick aortic valve cusps ( J:273437 )
• at P0 and in adult mice
thick pulmonary valve cusps ( J:273437 )
• at P0 and in adult mice
decreased cardiac muscle contractility ( J:273437 )
• decreased ejection fraction and fractional shortening

cellular
decreased apoptosis ( J:273437 )
• reduced apoptosis of endothelial-derived valvar interstitial cells
increased cell proliferation ( J:273437 )
• prolonged cell proliferation of endothelial-derived valvar interstitial cells

muscle
increased myocardial fiber size ( J:273437 )
• increased cross sectional area
decreased cardiac muscle contractility ( J:273437 )
• decreased ejection fraction and fractional shortening

growth/size/body
increased heart weight ( J:273437 )
• relative to body weight
cardiac hypertrophy ( J:273437 )
• severe at 36 weeks of age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory