Phenotypes associated with this allele

• Allele Symbol: Tefm^tm1.1Lrsn
• Allele Name: targeted mutation 1.1, Nils-Goran Larsson
• Allele ID: MGI:6360156
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tefm^tm1.1Lrsn/Tefm^tm1.1Lrsn Tg(Ckmm-cre)5Khn/0	involves: C57BL/6N * FVB	MGI:6360162

Genotype
MGI:6360162

cn1

• Allelic Composition: Tefm^tm1.1Lrsn/Tefm^tm1.1Lrsn; Tg(Ckmm-cre)5Khn/0
• Genetic Background: involves: C57BL/6N * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:276874 )

• maximal longevity of 9 weeks

cardiovascular system

abnormal myocardial fiber morphology ( J:276874 )

• disrupted mitochondrial alignment and disorganized cristae with a 1.5-fold increase in mitochondrial mass and mtDNA

enlarged heart ( J:276874 )

increased heart weight ( J:276874 )

growth/size/body

enlarged heart ( J:276874 )

increased heart weight ( J:276874 )

decreased body weight ( J:276874 )

cellular

abnormal mitochondrial morphology ( J:276874 )

• disrupted mitochondrial alignment and disorganized cristae with a 1.5-fold increase in mitochondrial mass and mtDNA in the heart

increased mitochondrial DNA content ( J:276874 )

• in the heart

abnormal mitochondrial ATP synthesis coupled electron transport ( J:276874 )

• reduced OXPHOS capacity in the heart

muscle

abnormal myocardial fiber morphology ( J:276874 )

• disrupted mitochondrial alignment and disorganized cristae with a 1.5-fold increase in mitochondrial mass and mtDNA