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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tefmtm1.1Lrsn
targeted mutation 1.1, Nils-Goran Larsson
MGI:6360156
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Tefmtm1.1Lrsn/Tefmtm1.1Lrsn
Tg(Ckmm-cre)5Khn/0 		involves: C57BL/6N * FVB MGI:6360162


Genotype
MGI:6360162
cn1
Allelic
Composition		 Tefmtm1.1Lrsn/Tefmtm1.1Lrsn
Tg(Ckmm-cre)5Khn/0
Genetic
Background		 involves: C57BL/6N * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tefmtm1.1Lrsn mutation (0 available); any Tefm mutation (50 available)
Tg(Ckmm-cre)5Khn mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:276874 )
• maximal longevity of 9 weeks

cardiovascular system
abnormal myocardial fiber mitochondrial morphology ( J:276874 )
• disrupted mitochondrial alignment and disorganized cristae with a 1.5-fold increase in mitochondrial mass and mtDNA

growth/size/body
enlarged heart ( J:276874 )
increased heart weight ( J:276874 )
decreased body weight ( J:276874 )

cellular
abnormal myocardial fiber mitochondrial morphology ( J:276874 )
• disrupted mitochondrial alignment and disorganized cristae with a 1.5-fold increase in mitochondrial mass and mtDNA

muscle
abnormal myocardial fiber mitochondrial morphology ( J:276874 )
• disrupted mitochondrial alignment and disorganized cristae with a 1.5-fold increase in mitochondrial mass and mtDNA




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory