Phenotypes associated with this allele

• Allele Symbol: Mettl4^em1Dfel
• Allele Name: endonuclease-mediated mutation 1, Douglas E Feldman
• Allele ID: MGI:6358564
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mettl4^em1Dfel/Mettl4^em1Dfel	involves: 129/Sv * C57BL/6N	MGI:6358567

Genotype
MGI:6358567

hm1

• Allelic Composition: Mettl4^em1Dfel/Mettl4^em1Dfel
• Genetic Background: involves: 129/Sv * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

enlarged spleen ( J:278437 )

• in adult (10-12 weeks old) Mettl4 KO mice

anemia ( J:278437 )

• in adult (10-12 weeks old) Mettl4 KO mice

decreased leukocyte cell number ( J:278437 )

• in adult (10-12 weeks old) Mettl4 KO mice

craniofacial

abnormal craniofacial morphology ( J:278437 )

• approximately 6.4% of incross progeny displayed gross anatomical defects

mortality/aging

moribund ( J:278437 )

• Adult (10-12 weeks old) Mettl4 KO mice were moribund

reproductive system

reduced fertility ( J:278437 )

• homozygous incrosses produced significantly smaller litters than control

immune system

enlarged spleen ( J:278437 )

• in adult (10-12 weeks old) Mettl4 KO mice

decreased leukocyte cell number ( J:278437 )

• in adult (10-12 weeks old) Mettl4 KO mice

vision/eye

anophthalmia ( J:278437 )

• approximately 6.4% of incross progeny displayed gross anatomical defects

growth/size/body

enlarged spleen ( J:278437 )

• in adult (10-12 weeks old) Mettl4 KO mice