Phenotypes associated with this allele

• Allele Symbol: Eftud2^em2Lajm
• Allele Name: endonuclease-mediated mutation 2, Loydie Anne Jerome-Majewska
• Allele ID: MGI:6358539
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Eftud2^em2Lajm/Eftud2^em2Lajm	involves: CD-1 * FVB/N	MGI:6358548
ht2	Eftud2^em2Lajm/Eftud2^+	involves: CD-1 * FVB/N	MGI:6358540

Genotype
MGI:6358548

hm1

• Allelic Composition: Eftud2^em2Lajm/Eftud2^em2Lajm
• Genetic Background: involves: CD-1 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality at implantation, complete penetrance ( J:278323 )

• embryos are not found post-implantation but are present at the expected frequency at E3.5

• mutants do not survive ex vivo when cultured at E3.5

Genotype
MGI:6358540

ht2

• Allelic Composition: Eftud2^em2Lajm/Eftud2⁺
• Genetic Background: involves: CD-1 * FVB/N

embryo

embryonic growth retardation ( J:278323 )

• embryos are developmentally delayed between E8.5 and E9.5, having 2-3 pairs of somites less than wild-type littermates

• however, this reduction is no longer seen at E10.5

growth/size/body

embryonic growth retardation ( J:278323 )

• embryos are developmentally delayed between E8.5 and E9.5, having 2-3 pairs of somites less than wild-type littermates

• however, this reduction is no longer seen at E10.5

reproductive system

reproductive system phenotype ( J:278323 )

N • mice are viable and fertile

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	mandibulofacial dysostosis, Guion-Almeida type	DOID:0080196	OMIM:610536	J:278323