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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Commd8tm1.1Ksuz
targeted mutation 1.1, Kazuhiro Suzuki
MGI:6358283
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Commd8tm1.1Ksuz/Commd8tm1.1Ksuz
Ightm1Mnz/Igh+
Cd79atm1(cre)Reth/Cd79a+ 		involves: 129P2/OlaHsd * BALB/c * C57BL/6NSlc * SJL MGI:6358358
cn2
 		Cd79atm1(cre)Reth/Cd79a+
Commd8tm1.1Ksuz/Commd8tm1.1Ksuz 		involves: BALB/c * C57BL/6NSlc * SJL MGI:6358356


Genotype
MGI:6358358
cn1
Allelic
Composition		 Commd8tm1.1Ksuz/Commd8tm1.1Ksuz
Ightm1Mnz/Igh+
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c * C57BL/6NSlc * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (22 available)
Commd8tm1.1Ksuz mutation (0 available); any Commd8 mutation (15 available)
Ightm1Mnz mutation (4 available); any Igh mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal spleen B cell follicle morphology ( J:278399 )
• 3 hours after antigen injection, B cells fail to accumulate in the outer follicle instead had already arrived at the B-T boundary unlike in control cells
• however, B cells are distributed at the B-T boundary after 6 hours

hematopoietic system
abnormal spleen B cell follicle morphology ( J:278399 )
• 3 hours after antigen injection, B cells fail to accumulate in the outer follicle instead had already arrived at the B-T boundary unlike in control cells
• however, B cells are distributed at the B-T boundary after 6 hours




Genotype
MGI:6358356
cn2
Allelic
Composition		 Cd79atm1(cre)Reth/Cd79a+
Commd8tm1.1Ksuz/Commd8tm1.1Ksuz
Genetic
Background		 involves: BALB/c * C57BL/6NSlc * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (22 available)
Commd8tm1.1Ksuz mutation (0 available); any Commd8 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:278399 )
N
• mice exhibit normal size of developing B cell subsets and serum levels of IgA in unimmunized mice
decreased mature B cell number ( J:278399 )
• in the bone marrow, blood, and spleen
decreased follicular B cell number ( J:278399 )
• in the bone marrow, blood, and spleen
abnormal plasmablast number ( J:278399 )
• decreased after immunization with NP-CGG compared with controls
abnormal spleen B cell follicle morphology ( J:278399 )
• less defined boundaries
decreased spleen germinal center number ( J:278399 )
• after immunization with NP-CGG compared with controls
abnormal follicular B cell physiology ( J:278399 )
• impaired B cell migration in response to CXCL12, CXCL13, CCL19 and 7alpha,25-HC
• bone marrow chimeras exhibit increased migration of B cells from follicles compared with wild-derived cells
• however, response to S1P is normal as is lymph node egression
decreased IgG1 level ( J:278399 )
• in unimmunized mice and after immunization with NP-CGG compared with controls
decreased IgG2b level ( J:278399 )
• in unimmunized mice
decreased IgG2c level ( J:278399 )
• in unimmunized mice
decreased IgG3 level ( J:278399 )
• in unimmunized mice
decreased IgM level ( J:278399 )
• after immunization with NP-CGG compared with controls
• however, unimmunized mice exhibit normal levels of IgM

hematopoietic system
decreased mature B cell number ( J:278399 )
• in the bone marrow, blood, and spleen
decreased follicular B cell number ( J:278399 )
• in the bone marrow, blood, and spleen
abnormal plasmablast number ( J:278399 )
• decreased after immunization with NP-CGG compared with controls
abnormal spleen B cell follicle morphology ( J:278399 )
• less defined boundaries
decreased spleen germinal center number ( J:278399 )
• after immunization with NP-CGG compared with controls
abnormal follicular B cell physiology ( J:278399 )
• impaired B cell migration in response to CXCL12, CXCL13, CCL19 and 7alpha,25-HC
• bone marrow chimeras exhibit increased migration of B cells from follicles compared with wild-derived cells
• however, response to S1P is normal as is lymph node egression
decreased IgG1 level ( J:278399 )
• in unimmunized mice and after immunization with NP-CGG compared with controls
decreased IgG2b level ( J:278399 )
• in unimmunized mice
decreased IgG2c level ( J:278399 )
• in unimmunized mice
decreased IgG3 level ( J:278399 )
• in unimmunized mice
decreased IgM level ( J:278399 )
• after immunization with NP-CGG compared with controls
• however, unimmunized mice exhibit normal levels of IgM




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory