Analysis Tools
vision/eye
| N |
• young mice exhibit normal ERG and visual placement responses
• adult mice exhibit normal inner and outer nuclear layer thickness
• mice exhibit normal distribution of horizontal and bipolar cells as well as Mueller cell proliferation
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• opsin is mislocalized to the inner segments, the perinuclear cytoplasm in the outer nuclear layer and the rod synaptic terminals in the outer plexiform layer
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• amacrine cell interneuron organization is disrupted with localization of Pax6+ cells throughout the inner nuclear layer
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• increased cellular proliferation in the inner nuclear layer and retinal ganglion layer, likely interneuron cells
• increased amacrine cell proliferation with reduced mature amacrine cell marker expression
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• of interneurons in the inner nuclear layer
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nervous system
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• amacrine cell interneuron organization is disrupted with localization of Pax6+ cells throughout the inner nuclear layer
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cellular
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• of interneurons in the inner nuclear layer
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