Phenotypes associated with this allele

• Allele Symbol: Coa8^em1Zev
• Allele Name: endonuclease-mediated mutation 1, Massimo Zeviani
• Allele ID: MGI:6355916
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Coa8^em1Zev/Coa8^em1Zev	FVB/NJ-Coa8^em1Zev	MGI:6357857

Genotype
MGI:6357857

hm1

• Allelic Composition: Coa8^em1Zev/Coa8^em1Zev
• Genetic Background: FVB/NJ-Coa8^em1Zev

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased exploration in new environment ( J:277865 )

• in Y-maze test at ages 6 and 12 months

impaired coordination ( J:277865 , J:277865 )

♀ • significantly reduced time on rotarod at ages 3, 6 and 12 months (J:277865)

♂ • significantly reduced time on rotarod at age 12 months (J:277865)

decreased locomotor activity ( J:277865 )

• reduced horizontal movement in activity cage at age 12 months

impaired exercise endurance ( J:277865 )

• significantly reduced running distance on treadmill at ages 3 and 12 months

cellular

abnormal respiratory electron transport chain ( J:277865 )

• reduced cytochrome c oxidase (COX) activity in skeletal muscle, kidney, heart, brain, and liver at age 3 months

• reduced cytochrome c oxidase (COX) activity in skeletal muscle, brain, and liver at age 12 months

• normal activity of respiratory chain components other than COX

homeostasis/metabolism

impaired exercise endurance ( J:277865 )

• significantly reduced running distance on treadmill at ages 3 and 12 months

muscle

muscle phenotype ( J:277865 )

N • skeletal muscle fiber morphology