Phenotypes associated with this allele

• Allele Symbol: Pik3c2a^tm1.1Arte
• Allele Name: targeted mutation 1.1, TaconicArtemis
• Allele ID: MGI:6355467
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pik3c2a^tm1.1Arte/Pik3c2a^tm1.1Arte	involves: C57BL/6J * C57BL/6NTac	MGI:8386639
ht2	Pik3c2a^tm1.1Arte/Pik3c2a^+	Not Specified	MGI:8386640

Genotype
MGI:8386639

hm1

• Allelic Composition: Pik3c2a^tm1.1Arte/Pik3c2a^tm1.1Arte
• Genetic Background: involves: C57BL/6J * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality prior to tooth bud stage, complete penetrance ( J:236061 )

• no embryos beyond E10.5-11.5

Genotype
MGI:8386640

ht2

• Allelic Composition: Pik3c2a^tm1.1Arte/Pik3c2a⁺
• Genetic Background: Not Specified

adipose tissue

increased white adipose tissue amount ( J:236061 )

♂ • larger adipocytes in perirenal and epididymal WAT at age 32 weeks

increased total body fat amount ( J:236061 )

♂ • more bodyfat with concomitant reduction in relative muscle mass at age 32 weeks

increased white fat cell size ( J:236061 )

♂ • in perirenal and epididymal WAT at age 32 weeks

behavior/neurological

behavior/neurological phenotype ( J:236061 )

♂N • normal cumulative food intake over 7 and 28 days at age 12 weeks

increased food intake ( J:236061 )

♂ • increased cumulative food intake over 7 and 28 days at age 12 weeks

embryo

embryo phenotype ( J:236061 )

N • viable

growth/size/body

growth/size/body region phenotype ( J:236061 , J:236061 , J:236061 )

N • no obvious morphological phenotype (J:236061)

♀N • normal age-related body weight gain (J:236061)

♂N • normal organ and body weight at age 12 weeks (J:236061)

♂N • normal body length at age 32 weeks (J:236061)

increased susceptibility to age related obesity ( J:236061 )

♂ • at age 32 weeks

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:236061 , J:236061 )

N • normal glucose homeostasis and insulin sensitivity at age 12 weeks (J:236061)

♀N • normal circulating leptin levels at age 12 and 32 weeks (J:236061)

♀N • normal results from glucose and insulin tolerance tests (J:236061)

hyperglycemia ( J:236061 )

♂ • under fed conditions at age 32 weeks

♂ • normal under fasted conditions at age 32 weeks

increased circulating insulin level ( J:236061 )

♂ • at age 32 weeks

increased circulating leptin level ( J:236061 )

♂ • ~25% higher at age 12 and 32 weeks

insulin resistance ( J:236061 )

♂ • at age 32 weeks

decreased response to leptin ( J:236061 )

♂ • reduced ability of systemically administered to reduce appetite (increased leptin resistance) at age 12 weeks

liver/biliary system

increased susceptibility to age-related hepatic steatosis ( J:236061 )

♂ • in 50% of mice at age 32 weeks

mortality/aging

mortality/aging ( J:236061 )

N • viable

reproductive system

reproductive system phenotype ( J:236061 )

N • fertile