Pik3c2a^tm1.1Arte
Targeted Allele Detail

Summary

• Symbol: Pik3c2a^tm1.1Arte
• Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; targeted mutation 1.1, TaconicArtemis
• MGI ID: MGI:6355467
• Synonyms: C2alpha^D1268A, Pik3c2a^{tm1521(D1268A)Arte}
• Gene: Pik3c2a Location: Chr7:115936500-116042684 bp, - strand Genetic Position: Chr7, 61.62 cM
• Alliance: Pik3c2a^tm1.1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:236061
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Single point mutation
• Mutation details:

  The genomic DNA encoding the ATP-binding DFG motif is mutated to encode an AFG sequence, which is predicted to result in the production of a kinase-dead protein. The FRT site flanked neomycin resistance gene cassette that was inserted into intron 23 was removed through subsequent Flp-mediated recombination. (J:236061)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pik3c2a Mutation: 100 strains or lines available

References

• Original: J:236061 Alliouachene S, et al., Inactivation of class II PI3K-C2alpha induces leptin resistance, age-dependent insulin resistance and obesity in male mice. Diabetologia. 2016 Jul;59(7):1503-12
• All: 1 reference(s)