Pik3ca^tm1521Arte
Targeted Allele Detail

Summary

• Symbol: Pik3ca^tm1521Arte
• Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; targeted mutation 1521, TaconicArtemis
• MGI ID: MGI:6355467
• Synonyms: C2alpha^D1268A, Pik3c2^{tm1521(D1268A)Arte}
• Gene: Pik3ca Location: Chr3:32451203-32520256 bp, + strand Genetic Position: Chr3, 15.7 cM, cytoband B
• Alliance: Pik3ca^tm1521Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:236061
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutation: Nucleotide substitutions
• Mutation details: The genomic DNA encoding the ATP-binding DFG motif is mutated to encode an AFG sequence, rwhich is predicted to result in the production of a kinase-dead protein. (J:236061)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pik3ca Mutation: 66 strains or lines available

References

• Original: J:236061 Alliouachene S, et al., Inactivation of class II PI3K-C2alpha induces leptin resistance, age-dependent insulin resistance and obesity in male mice. Diabetologia. 2016 Jul;59(7):1503-12
• All: 1 reference(s)