All Phenotypes Tardbp<Rgsc2223> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tardbp^Rgsc2223
Riken Genomic Sciences Center 2223
MGI:6355456

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tardbp^Rgsc2223/Tardbp^Rgsc2223	C57BL/6J-Tardbp^Rgsc2223	MGI:6400961
hm2	Tardbp^Rgsc2223/Tardbp^Rgsc2223	involves: C57BL/6JJcl * DBA/2J	MGI:6400959
ht3	Tardbp^Rgsc2223/Tardbp^Rgsc2268	involves: C57BL/6JJcl * DBA/2J	MGI:6400965

Allelic Composition	Tardbp^Rgsc2223/Tardbp^Rgsc2223
Genetic Background	C57BL/6J-Tardbp^Rgsc2223

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tardbp^Rgsc2223 mutation (6 available); any Tardbp mutation (82 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:265666 )

Allelic Composition	Tardbp^Rgsc2223/Tardbp^Rgsc2223
Genetic Background	involves: C57BL/6JJcl * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tardbp^Rgsc2223 mutation (6 available); any Tardbp mutation (82 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

decreased grip strength ( J:265666 )

• 38% reduction in tetanic strength in tibialis anterior muscles at age 24 month

• progressive grip strength deficit from age 12 months

mortality/aging

mortality/aging ( J:265666 )

• viable

nervous system

decreased motor neuron number ( J:265666 )

• 28% reduction in sciatic MNs at L4-L5 at age 24 months

• 15% reduction in motor units innervating extensor digitorum (EDL) muscle at age 24 months

Allelic Composition	Tardbp^Rgsc2223/Tardbp^Rgsc2268
Genetic Background	involves: C57BL/6JJcl * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tardbp^Rgsc2223 mutation (6 available); any Tardbp mutation (82 available)
Tardbp^Rgsc2268 mutation (6 available); any Tardbp mutation (82 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:265666 )

• fewer than expected mice are born

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/30/2025 MGI 6.24