All Phenotypes Tardbp<Rgsc2223> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tardbp^Rgsc2223
Riken Genomic Sciences Center 2223
MGI:6355456

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tardbp^Rgsc2223/Tardbp^Rgsc2223	C57BL/6J-Tardbp^Rgsc2223	MGI:6400961
hm2	Tardbp^Rgsc2223/Tardbp^Rgsc2223	involves: C57BL/6JJcl * DBA/2J	MGI:6400959
ht3	Tardbp^Rgsc2223/Tardbp^Rgsc2268	involves: C57BL/6JJcl * DBA/2J	MGI:6400965

Allelic Composition	Tardbp^Rgsc2223/Tardbp^Rgsc2223
Genetic Background	C57BL/6J-Tardbp^Rgsc2223

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tardbp^Rgsc2223 mutation (6 available); any Tardbp mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:265666 )

Allelic Composition	Tardbp^Rgsc2223/Tardbp^Rgsc2223
Genetic Background	involves: C57BL/6JJcl * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tardbp^Rgsc2223 mutation (6 available); any Tardbp mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

decreased grip strength ( J:265666 )

• 38% reduction in tetanic strength in tibialis anterior muscles at age 24 month

• progressive grip strength deficit from age 12 months

mortality/aging

mortality/aging ( J:265666 )

• viable

nervous system

decreased motor neuron number ( J:265666 )

• 28% reduction in sciatic MNs at L4-L5 at age 24 months

• 15% reduction in motor units innervating extensor digitorum (EDL) muscle at age 24 months

Allelic Composition	Tardbp^Rgsc2223/Tardbp^Rgsc2268
Genetic Background	involves: C57BL/6JJcl * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tardbp^Rgsc2223 mutation (6 available); any Tardbp mutation (60 available)
Tardbp^Rgsc2268 mutation (6 available); any Tardbp mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:265666 )

• fewer than expected mice are born

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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