Phenotypes associated with this allele

• Allele Symbol: Zic2^iso
• Allele Name: isomeric
• Allele ID: MGI:6355448
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zic2^iso/Zic2^iso	involves: C3H/HeH * C57BL/6	MGI:6369712

Genotype
MGI:6369712

hm1

• Allelic Composition: Zic2^iso/Zic2^iso
• Genetic Background: involves: C3H/HeH * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

right aortic arch ( J:268103 )

• in 5 of 17 E14.5 embryos

abnormal hepatic vein connection ( J:268103 )

• hepatic vein drainage direct to atria in 2 of 16 E14.5 embryos

left sided inferior vena cava ( J:268103 )

• in 5 of 16 E14.5 embryos

double outlet right ventricle ( J:268103 )

• in 5 of 13 E14.5 embryos

right atrial isomerism ( J:268103 )

• two right atria in majority of E14.5 embryos

• bilateral systemic venous sinus in 10 of 15 E14.5 embryos

atrial septal defect ( J:268103 )

• in 8 of 11 E14.5 embryos

dextrocardia ( J:268103 )

• in 4 of 16 E14.5 embryos

mesocardia ( J:268103 )

• in 7 of 16 E14.5 embryos

abnormal heart ventricle morphology ( J:268103 )

• reversed heart ventricles in 6 of 13 E14.5 embryos

ventricular septal defect ( J:268103 )

• in 11 of 15 E14.5 embryos

digestive/alimentary system

right-sided stomach ( J:268103 )

• in 7 of 17 E14.5 embryos

embryo

spina bifida ( J:268103 )

• in E14.5 embryos

endocrine/exocrine glands

abnormal pancreas morphology ( J:268103 )

• right sided pancreas in 5 of 14 E14.5 embryos

growth/size/body

heterotaxia ( J:268103 )

• bilateral systemic venous sinus in 10 of 15 E14.5 embryos

• reversed heart ventricles in 6 of 13 E14.5 embryos

right-sided stomach ( J:268103 )

• in 7 of 17 E14.5 embryos

right-sided isomerism ( J:268103 )

• right sided spleen in 2 of 6 E14.5 embryos

• right sided pancreas in 5 of 14 E14.5 embryos

right atrial isomerism ( J:268103 )

• two right atria in majority of E14.5 embryos

• bilateral systemic venous sinus in 10 of 15 E14.5 embryos

right pulmonary isomerism ( J:268103 )

• in majority of E14.5 embryos

• in 4 of 17 E14.5 embryos

hematopoietic system

abnormal spleen morphology ( J:268103 )

• right sided spleen in 2 of 6 E14.5 embryos

abnormal spleen size ( J:268103 )

• reduced or absent spleen in 1 of 6 E14.5 embryos

absent spleen ( J:268103 )

• reduced or absent spleen in 1 of 6 E14.5 embryos

immune system

abnormal spleen morphology ( J:268103 )

• right sided spleen in 2 of 6 E14.5 embryos

abnormal spleen size ( J:268103 )

• reduced or absent spleen in 1 of 6 E14.5 embryos

absent spleen ( J:268103 )

• reduced or absent spleen in 1 of 6 E14.5 embryos

limbs/digits/tail

curly tail ( J:268103 )

• in E14.5 embryos

nervous system

spina bifida ( J:268103 )

• in E14.5 embryos

alobar holoprosencephaly ( J:268103 )

• alobar form in majority of E14.5 embryos

exencephaly ( J:268103 )

• in E14.5 embryos

respiratory system

right pulmonary isomerism ( J:268103 )

• in majority of E14.5 embryos

• in 4 of 17 E14.5 embryos

vision/eye

cyclopia ( J:268103 )

• in majority of E14.5 embryos

ocular hypotelorism ( J:268103 )

• in 6 of 17 E14.5 embryos

anophthalmia ( J:268103 )

• in 3 of 17 E14.5 embryos