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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Orc1tm1.2Gle
targeted mutation 1.2, Gustavo Leone
MGI:6355394
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Orc1tm1.2Gle/Orc1tm1.2Gle involves: C57BL/6 * SJL MGI:7408227
cn2
 		Orc1tm1.1Gle/Orc1tm1.2Gle
Edil3Tg(Sox2-cre)1Amc/Edil3+ 		involves: C57BL/6 * CBA * SJL MGI:7408228
cn3
 		Orc1tm1.1Gle/Orc1tm1.2Gle
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ 		involves: C57BL/6 * DBA * SJL MGI:7408239
cn4
 		Orc1tm1.1Gle/Orc1tm1.2Gle
Prl2c2tm1(cre)Gle/Prl2c2+ 		involves: C57BL/6 * SJL MGI:7408236


Genotype
MGI:7408227
hm1
Allelic
Composition		 Orc1tm1.2Gle/Orc1tm1.2Gle
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Orc1tm1.2Gle mutation (0 available); any Orc1 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality at implantation, complete penetrance ( J:272584 )
• although E3.5 blastocysts are recovered at the expected frequency, no viable embryos are found beyond E6.5 indicating peri-implantation lethality




Genotype
MGI:7408228
cn2
Allelic
Composition		 Orc1tm1.1Gle/Orc1tm1.2Gle
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background		 involves: C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (42 available)
Orc1tm1.1Gle mutation (0 available); any Orc1 mutation (60 available)
Orc1tm1.2Gle mutation (0 available); any Orc1 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:272584 )
• no live mice are recovered at E10.5 or at 2 weeks of age




Genotype
MGI:7408239
cn3
Allelic
Composition		 Orc1tm1.1Gle/Orc1tm1.2Gle
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: C57BL/6 * DBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Orc1tm1.1Gle mutation (0 available); any Orc1 mutation (60 available)
Orc1tm1.2Gle mutation (0 available); any Orc1 mutation (60 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
increased hepatocyte karyomegaly ( J:272584 )
• at 3 weeks of age, hepatocytes are strikingly larger with larger nuclei than controls
decreased hepatocyte number ( J:272584 )
• fewer hepatocytes are observed relative to controls
• however, liver gross morphology is normal from 3 weeks to 3 months and liver to body weight ratios remain normal up to 6 months of age

cellular
polyploidy ( J:272584 )
• at 3 weeks of age, an increased proportion of hepatocytes with 4C DNA content is observed
• by 3 months of age, a larger proportion of hepatocytes with 8C or greater DNA content is observed
increased hepatocyte karyomegaly ( J:272584 )
• at 3 weeks of age, hepatocytes are strikingly larger with larger nuclei than controls
abnormal DNA replication ( J:272584 )
• hepatocytes endoreduplicate their genomic DNA prematurely

homeostasis/metabolism
abnormal DNA replication ( J:272584 )
• hepatocytes endoreduplicate their genomic DNA prematurely




Genotype
MGI:7408236
cn4
Allelic
Composition		 Orc1tm1.1Gle/Orc1tm1.2Gle
Prl2c2tm1(cre)Gle/Prl2c2+
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Orc1tm1.1Gle mutation (0 available); any Orc1 mutation (60 available)
Orc1tm1.2Gle mutation (0 available); any Orc1 mutation (60 available)
Prl2c2tm1(cre)Gle mutation (0 available); any Prl2c2 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:272584 )
• placental development is normal, embryos are carried to term and all pups born exhibit no apparent abnormalities




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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory