Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxw11tm1Nakay mutation
(0 available);
any
Fbxw11 mutation
(71 available)
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mortality/aging
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• although present at normal Mendelian ratios up to E9.5, homozygous mutant embryos are resorbed at E10.5, with no viable embryos detected at P0
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embryo
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• developmental arrest before E10.5
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• embryos are developmentally delayed at E9.5
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• accumulation of Cdkn2a (an inhibitor of cell cycle progression, also known as p19ARF) mRNA in the yolk sac at E9.5
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growth/size/body
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• embryos are developmentally delayed at E9.5
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxw11tm1Nakay mutation
(0 available);
any
Fbxw11 mutation
(71 available)
Fbxw11tm2Nakay mutation
(0 available);
any
Fbxw11 mutation
(71 available)
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cellular
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• after Cre retrovirus infection (to delete the floxed allele), primary mouse embryonic fibroblasts (MEFs) derived from E13.5 embryos show significantly decreased cell proliferation relative to wild-type MEFs
• no differences in oncogene-induced cellular replicative senescence or apoptosis are observed
• defect in MEF proliferation can be rescued by beta-TrCP2 overexpression, but not by beta-TrCP1 overexpression
• arrest in MEF proliferation is induced by stabilization and abnormal accumulation of Cdkn2a (also known as p19ARF)
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm1Rdp mutation
(6 available);
any
Cdkn2a mutation
(62 available)
Fbxw11tm1Nakay mutation
(0 available);
any
Fbxw11 mutation
(71 available)
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mortality/aging
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• phenotype is stated to be identical to that of Fbxw11tm1Nakay homozygotes, indicating that concomitant inactivation of Cdkn2a does not rescue the lethal phenotype
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embryo
growth/size/body