Analysis Tools
cardiovascular system
|
• by E9.5, the yolk sacs of many homozygous embryos lack proper vascular development
|
|
• by E10.5, all homozygous embryos exhibit an abnormal heart shape
|
craniofacial
|
• by E9.5, most homozygous embryos exhibit branchial arch/pouch defects
|
|
• some older E8.5 homozygous embryos exhibit an abnormally shaped head, while most are relatively normal at E8.5
• at E9.5, nearly all have abnormally shaped heads; by E10.5, all exhibit abnormal head shapes
|
embryo
|
• by E9.5, the yolk sacs of many homozygous embryos lack proper vascular development
|
|
• by E9.5, most homozygous embryos exhibit branchial arch/pouch defects
|
|
• by E9.5, half of the homozygous embryos exhibit turning defects
(J:374598)
|
|
 |
IMPC - JAX
(J:211773)
|
|
• at E9.5, many homozygous embryos remain incompletely turned, although the gut tube has closed and the liver bud has initiated formation
• by E10.5, most homozygous embryos display incomplete turning
|
|
• at E9.5, slightly less than half of the homozygous embryos are developmentally delayed; by E10.5, all exhibit an overall delay relative to control littermates
(J:374598)
• however, all have initiated normal heart, foregut and neural tube development at E8.5, and all germ layers are formed at E9.5
(J:374598)
|
|
|
|
IMPC - JAX
(J:211773)
|
|
• by E9.5, all homozygous embryos are smaller than control littermates
|
|
• by E9.5, half of the homozygous embryos exhibit incomplete cranial neural tube closure
|
|
• by E9.5, most homozygous embryos exhibit branchial arch/pouch defects
|
|
• at E9.5, all placentas exhibit an expanded Tpbpa+ spongiotrophoblast layer
• however, the labyrinth zone develops normally
|
growth/size/body
|
• some older E8.5 homozygous embryos exhibit an abnormally shaped head, while most are relatively normal at E8.5
• at E9.5, nearly all have abnormally shaped heads; by E10.5, all exhibit abnormal head shapes
|
|
• at E9.5, slightly less than half of the homozygous embryos are developmentally delayed; by E10.5, all exhibit an overall delay relative to control littermates
(J:374598)
• however, all have initiated normal heart, foregut and neural tube development at E8.5, and all germ layers are formed at E9.5
(J:374598)
|
|
|
|
IMPC - JAX
(J:211773)
|
|
• by E9.5, all homozygous embryos are smaller than control littermates
|
limbs/digits/tail
|
• by E10.5, most homozygous embryos exhibit abnormal tail shape
|
mortality/aging
|
IMPC - JAX
|
|
• homozygous embryos are present in Mendelian ratios at E8.5 and E9.5, but are underrepresented at E10.5 and absent at E12.5
|
nervous system
|
• by E9.5, half of the homozygous embryos exhibit incomplete cranial neural tube closure
|
|
IMPC - JAX
|
