Phenotypes associated with this allele

• Allele Symbol: Npffr2^tm1.1Hhzg
• Allele Name: targeted mutation 1.1, H Herzog
• Allele ID: MGI:6313711
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Npffr2^tm1.1Hhzg/Npffr2^tm1.1Hhzg	involves: C57BL/6	MGI:6314311

Genotype
MGI:6314311

hm1

• Allelic Composition: Npffr2^tm1.1Hhzg/Npffr2^tm1.1Hhzg
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

increased litter size ( J:267918 )

adipose tissue

decreased white adipose tissue amount ( J:267918 )

♀ • in female, but not male, mice fed a standard chow diet

increased white adipose tissue amount ( J:267918 )

• in female and male mice when fed a standard chow diet and more so when fed a high-fat diet

increased epididymal fat pad weight ( J:267918 )

• in male mice when fed a standard chow diet and more so when fed a high-fat diet

• in female mice when fed a high-fat diet

decreased inguinal fat pad weight ( J:267918 )

♀ • in female mice when fed a standard chow diet

increased inguinal fat pad weight ( J:267918 )

• in female and male mice when fed a high-fat diet

decreased mesenteric fat pad weight ( J:267918 )

♀ • female mice fed a standard chow diet

increased mesenteric fat pad weight ( J:267918 )

• in female and male mice when fed a high-fat diet

• however, male mice fed a standard chow diet exhibit normal levels

decreased retroperitoneal fat pad weight ( J:267918 )

♀ • female mice fed a standard chow diet

increased retroperitoneal fat pad weight ( J:267918 )

• in female and male mice when fed a high-fat diet

abnormal brown adipose tissue thermogenesis ( J:267918 )

• impaired to diet-induced brown fat thermogenesis in female and male mice fed a high-fat diet

• however, cold-adapted brown adipose tissue thermogenesis is normal

homeostasis/metabolism

abnormal adaptive thermogenesis ( J:267918 )

• impaired to diet-induced thermogenesis in female and male mice fed a high-fat diet

• however, cold-adapted brown adipose tissue thermogenesis is normal

increased circulating insulin level ( J:267918 )

♀ • in female, but not male, mice when fed a standard chow diet and more so when fed a high-fat diet

increased circulating leptin level ( J:267918 )

• in female and male mice when fed a standard chow diet and more so when fed a high-fat diet

decreased energy expenditure ( J:267918 )

• in female and male mice fed a high-fat diet

increased susceptibility to diet-induced obesity ( J:267918 )

♂ • in male, but not female, mice when fed a high-fat diet

increased energy expenditure ( J:267918 )

♀ • in female, but not male, mice fed a standard chow diet during the light-phase

decreased respiratory quotient ( J:267918 )

♀ • in female, but not male, mice fed a high-fat diet

♀ • however, respiratory exchange ratio in both sexes is normal when fed standard chow

skeleton

short femur ( J:267918 )

♂ • slightly in male, but not female, mice

increased compact bone volume ( J:267918 )

♀ • in female, but not male, mice

increased compact bone thickness ( J:267918 )

♀ • in female, but not male, mice

increased bone trabecula number ( J:267918 )

♂ • in male, but not female, mice

increased trabecular bone mass ( J:267918 )

♂ • in male, but not female, mice

increased trabecular bone thickness ( J:267918 )

♂ • in male, but not female, mice

behavior/neurological

behavior/neurological phenotype ( J:267918 )

N • mice exhibit normal motor function, behavior in an open-field test and elevated plus maze, and unaltered responsiveness to thermal stimulus

decreased food intake ( J:267918 )

• in female mice when fed a high-fat diet

• in male mice when fed a standard chow or a high-fat diet

decreased locomotor activity ( J:267918 )

♀ • in female mice fed a high-fat diet unlike wild-type female mice

hyperactivity ( J:267918 )

♀ • in female, but not male, mice fed a standard chow diet during the light-phase

growth/size/body

decreased body weight ( J:267918 )

♂ • between 10 and 20 weeks of age when fed standard chow diet in male, but not female, mice

increased susceptibility to diet-induced obesity ( J:267918 )

♂ • in male, but not female, mice when fed a high-fat diet

nervous system

nervous system phenotype ( J:267918 )

N • mice exhibit normal motor function, behavior in an open-field test and elevated plus maze, and unaltered responsiveness to thermal stimulus

limbs/digits/tail

short femur ( J:267918 )

♂ • slightly in male, but not female, mice