Npffr2^tm1.1Hhzg
Targeted Allele Detail

Summary

• Symbol: Npffr2^tm1.1Hhzg
• Name: neuropeptide FF receptor 2; targeted mutation 1.1, H Herzog
• MGI ID: MGI:6313711
• Gene: Npffr2 Location: Chr5:89675288-89731599 bp, + strand Genetic Position: Chr5, 44.32 cM
• Alliance: Npffr2^tm1.1Hhzg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:267918
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2. A floxed neomycin resistance cassette was inserted downstream of exon 2. Cre-mediated recombination removed exon 2 and the selection cassette. (J:267918)

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Npffr2 Mutation: 24 strains or lines available

References

• Original: J:267918 Zhang L, et al., Diet-induced adaptive thermogenesis requires neuropeptide FF receptor-2 signalling. Nat Commun. 2018 Nov 9;9(1):4722
• All: 1 reference(s)