Phenotypes associated with this allele

• Allele Symbol: Prss3b^tm1.1Satom
• Allele Name: targeted mutation 1.1, Miklos Sahin-Toth
• Allele ID: MGI:6307777
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prss3b^tm1.1Satom/Prss3b^tm1.1Satom	B6(FVB)-Prss3b^tm1.1Satom	MGI:6307803
ht2	Prss3b^tm1.1Satom/Prss3b^+	B6(FVB)-Prss3b^tm1.1Satom	MGI:6307806

Genotype
MGI:6307803

hm1

• Allelic Composition: Prss3b^tm1.1Satom/Prss3b^tm1.1Satom
• Genetic Background: B6(FVB)-Prss3b^tm1.1Satom

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:267764 )

• mice die around 2 months of age

growth/size/body

decreased body size ( J:267764 )

Genotype
MGI:6307806

ht2

• Allelic Composition: Prss3b^tm1.1Satom/Prss3b⁺
• Genetic Background: B6(FVB)-Prss3b^tm1.1Satom

endocrine/exocrine glands

abnormal pancreas morphology ( J:267764 )

• variable size at 4 to 5 weeks of age

• however, size at 2 to 3 weeks is normal

decreased pancreatic acinar cell number ( J:267764 )

• beginning at 4 weeks of age

• replaced with adipose in late chronic pancreatitis

enlarged pancreatic islets ( J:267764 )

• somewhat in late chronic pancreatitis

increased pancreas weight ( J:267764 )

• in some mice at 4 to 5 weeks of age due to edema

small pancreas ( J:267764 )

• at 2 months of age

decreased pancreas weight ( J:267764 )

• in half of mice at 4 to 5 weeks of age

• in most mice at 2, 6 and 12 months of age

pancreas atrophy ( J:267764 )

• in late chronic pancreatitis

acute pancreas inflammation ( J:267764 )

• starting at 3 weeks and more frequently at 4 to 5 weeks of age with edema, infiltration of neutrophil granulocytes and macrophages, and widespread evidence of regeneration

chronic pancreas inflammation ( J:267764 )

• starting at 2 months and continuing through 6 and 12 months with adipose replacement proceeding to late chronic pancreatitis

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:267764 )

N • mice exhibit normal blood glucose at 12 months of age

decreased circulating amylase level ( J:267764 )

• at 4 to 5 weeks of age

digestive/alimentary system

decreased pancreatic acinar cell number ( J:267764 )

• beginning at 4 weeks of age

• replaced with adipose in late chronic pancreatitis

immune system

acute pancreas inflammation ( J:267764 )

• starting at 3 weeks and more frequently at 4 to 5 weeks of age with edema, infiltration of neutrophil granulocytes and macrophages, and widespread evidence of regeneration

chronic pancreas inflammation ( J:267764 )

• starting at 2 months and continuing through 6 and 12 months with adipose replacement proceeding to late chronic pancreatitis

growth/size/body

increased pancreas weight ( J:267764 )

• in some mice at 4 to 5 weeks of age due to edema

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pancreatitis		DOID:4989	OMIM:167800	J:267764