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Prss3btm1.1Satom
Targeted Allele Detail
Summary
Symbol: Prss3btm1.1Satom
Name: protease, serine 3B; targeted mutation 1.1, Miklos Sahin-Toth
MGI ID: MGI:6307777
Synonyms: T7D23A
Gene: Prss3b  Location: Chr6:41007202-41012443 bp, - strand  Genetic Position: Chr6, 19.1 cM
Alliance: Prss3btm1.1Satom page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:267764
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Modified isoform(s))
Mutation:    Nucleotide substitutions
 
Mutation detailsExon 2 was modified to produce the amino acid substitution of alanine for aspartic acid at position 23 (D23A). This mutation autoactivates to trypsin 50-fold faster than wild type. Cre-mediated recombination removed the floxed neomycin resistance cassette inserted into intron 1. (J:267764)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prss3b Mutation:  11 strains or lines available
Notes
C57BL/6 embryonic stem (ES) cells (Cyagen, Santa Clara, CA)
References
Original:  J:267764 Geisz A, et al., A preclinical model of chronic pancreatitis driven by trypsinogen autoactivation. Nat Commun. 2018 Nov 28;9(1):5033
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/24/2023
MGI 6.22
The Jackson Laboratory