Phenotypes associated with this allele

• Allele Symbol: Lmbr1l^m1Btlr
• Allele Name: mutation 1, Bruce Beutler
• Allele ID: MGI:6303733
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lmbr1l^m1Btlr/Lmbr1l^m1Btlr	C57BL/6J-Lmbr1l^m1Btlr	MGI:6303735

Genotype
MGI:6303735

hm1

• Allelic Composition: Lmbr1l^m1Btlr/Lmbr1l^m1Btlr
• Genetic Background: C57BL/6J-Lmbr1l^m1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell differentiation ( J:274568 )

• CD44 expression was increased on peripheral blood T cells

abnormal CD4-positive T cell differentiation ( J:274568 )

• CD44 expression was increased on peripheral blood CD4 T cells

abnormal CD8-positive, alpha-beta T cell differentiation ( J:274568 )

• CD44 expression was increased on peripheral blood CD8 T cells

increased neutrophil cell number ( J:274568 )

• increased frequencies of neutrophils in the peripheral blood

decreased dendritic cell number ( J:274568 )

• reduced frequencies of CD11b+ dendritic cells (DCs) in the peripheral blood

increased B-1 B cell number ( J:274568 )

• increased frequencies of B1 cells in the peripheral blood

decreased NK cell number ( J:274568 )

• reduced frequencies of natural killer (NK) cells in the peripheral blood

increased effector memory CD4-positive, alpha-beta T cell number ( J:274568 )

• increased frequencies of effector memory CD4 T cells in CD4 T cells in the peripheral blood

increased central memory CD8 positive, alpha-beta T cell number ( J:274568 )

• increased frequencies of central memory CD8 T cells in CD8 T cells in the peripheral blood

decreased CD8-positive, naive alpha-beta T cell number ( J:274568 )

• reduced frequencies of naive CD8 T cells in CD8 T cells in the peripheral blood

decreased T cell number ( J:274568 )

• reduced frequencies of T cells in the peripheral blood

decreased CD4-positive, alpha-beta T cell number ( J:274568 )

• reduced frequencies of CD4+ T cells and CD4+ T cells in CD3+ T cells in the peripheral blood

• reduced frequencies of naive CD4 T cells in CD4 T cells in the peripheral blood

decreased CD8-positive, alpha-beta T cell number ( J:274568 )

• reduced frequencies of CD8+ T cells in the peripheral blood

decreased NK T cell number ( J:274568 )

• reduced frequencies of NK T cells in the peripheral blood

increased macrophage cell number ( J:274568 )

• increased frequencies of macrophages in the peripheral blood

decreased IgE level ( J:274568 )

• the level of IgE was reduced after administration of OVA/alum

decreased IgG level ( J:274568 )

• the T-dependent antibody responses to ovalbumin administered with aluminum hydroxide and to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal) were diminished

decreased IgM level ( J:274568 )

• the T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll) was diminished

impaired natural killer cell mediated cytotoxicity ( J:274568 )

• decreased NK cell target killing

abnormal cytotoxic T cell physiology ( J:274568 )

• decreased cytotoxic T lymphocyte target killing

impaired humoral immune response ( J:274568 )

• the T-dependent antibody responses to ovalbumin administered with aluminum hydroxide and to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal) were diminished

• the T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll) was diminished

hematopoietic system

abnormal T cell differentiation ( J:274568 )

• CD44 expression was increased on peripheral blood T cells

abnormal CD4-positive T cell differentiation ( J:274568 )

• CD44 expression was increased on peripheral blood CD4 T cells

abnormal CD8-positive, alpha-beta T cell differentiation ( J:274568 )

• CD44 expression was increased on peripheral blood CD8 T cells

increased neutrophil cell number ( J:274568 )

• increased frequencies of neutrophils in the peripheral blood

decreased dendritic cell number ( J:274568 )

• reduced frequencies of CD11b+ dendritic cells (DCs) in the peripheral blood

increased B-1 B cell number ( J:274568 )

• increased frequencies of B1 cells in the peripheral blood

decreased NK cell number ( J:274568 )

• reduced frequencies of natural killer (NK) cells in the peripheral blood

increased effector memory CD4-positive, alpha-beta T cell number ( J:274568 )

• increased frequencies of effector memory CD4 T cells in CD4 T cells in the peripheral blood

increased central memory CD8 positive, alpha-beta T cell number ( J:274568 )

• increased frequencies of central memory CD8 T cells in CD8 T cells in the peripheral blood

decreased CD8-positive, naive alpha-beta T cell number ( J:274568 )

• reduced frequencies of naive CD8 T cells in CD8 T cells in the peripheral blood

decreased T cell number ( J:274568 )

• reduced frequencies of T cells in the peripheral blood

decreased CD4-positive, alpha-beta T cell number ( J:274568 )

• reduced frequencies of CD4+ T cells and CD4+ T cells in CD3+ T cells in the peripheral blood

• reduced frequencies of naive CD4 T cells in CD4 T cells in the peripheral blood

decreased CD8-positive, alpha-beta T cell number ( J:274568 )

• reduced frequencies of CD8+ T cells in the peripheral blood

decreased NK T cell number ( J:274568 )

• reduced frequencies of NK T cells in the peripheral blood

increased macrophage cell number ( J:274568 )

• increased frequencies of macrophages in the peripheral blood

decreased IgE level ( J:274568 )

• the level of IgE was reduced after administration of OVA/alum

decreased IgG level ( J:274568 )

• the T-dependent antibody responses to ovalbumin administered with aluminum hydroxide and to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal) were diminished

decreased IgM level ( J:274568 )

• the T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll) was diminished

impaired natural killer cell mediated cytotoxicity ( J:274568 )

• decreased NK cell target killing

abnormal cytotoxic T cell physiology ( J:274568 )

• decreased cytotoxic T lymphocyte target killing