Analysis Tools
cardiovascular system
|
• by E9.5, cardiac development is impaired
|
craniofacial
|
• at E8.5, the heads are almost always abnormally shaped; by E9.5, all homozygous embryos exhibit abnormal heads
|
embryo
|
• at E9.5, all homozygous embryos are unturned
|
|
IMPC - JAX
(J:211773)
MGI
• at E8.5, homozygous embryos are sometimes developmentally delayed
(J:374598)
• however, all three germ layers are present at E9.5
(J:374598)
|
|
• all homozygous embryos are extremely dysmorphic by E10.5
|
|
IMPC - JAX
|
|
• at E8.5, homozygous embryos are always smaller than control littermates
|
|
• by E9.5, the cranial neural tube is almost always open
|
|
• by E9.5, all homozygous embryos display caudal neural tube kinks
|
|
• at E8.5, homozygous embryos are distinguishable by an abnormal allantois that appears blebby and is sometimes branched
• by E9.5, the allantois is sometimes retracted and balled up, but can also be found tenuously attached to the placenta
|
|
• at E9.5, placentas exhibit multiple labyrinth zone defects
|
|
• at E9.5, the Tfeb+ labyrinth trophoblast layer fails to expand, remaining a thin layer
|
|
• at E9.5, placentas exhibit a diminished Tpbpa+ spongiotrophoblast layer
|
|
• at E9.5, Gcm1+ chorioallantoic branching is severely impaired
• by E10.5, placental defects are more severe than at E9.5
|
|
• at E9.5, placentas exhibit an abnormal chorioallantoic interface with a reduction in allantoic mesoderm and limited interface expansion
|
growth/size/body
|
• at E8.5, the heads are almost always abnormally shaped; by E9.5, all homozygous embryos exhibit abnormal heads
|
|
IMPC - JAX
(J:211773)
MGI
• at E8.5, homozygous embryos are sometimes developmentally delayed
(J:374598)
• however, all three germ layers are present at E9.5
(J:374598)
|
|
IMPC - JAX
|
|
• at E8.5, homozygous embryos are always smaller than control littermates
|
mortality/aging
|
IMPC - JAX
|
|
IMPC - JAX
|
|
• homozygous embryos are present in expected Mendelian ratios at E8.5 and E9.5 but absent at E12.5; all homozygous embryos are extremely dysmorphic by E10.5
|
nervous system
|
• by E9.5, the cranial neural tube is almost always open
|
|
• by E9.5, all homozygous embryos display caudal neural tube kinks
|
