Analysis Tools
cardiovascular system
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• intracellular aggregates containing the mutant protein and amyloid oligomer are seen in the hearts of 6 months old mice
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• mice exhibit cardiac hypertrophy, with increased heart weight/body weight ratios at 6 months of age
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• hearts exhibit mild apical cardiac fibrosis at 6 months of age
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• fractional shortening and ejection fraction are slightly reduced in 6 month old mice, indicating slightly reduced cardiac function
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• mice develop cardiac disease by 6 months of age
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cellular
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• oxidative phosphorylation ratio, respiratory control index, and oxygen consumption in state 3 are decreased in heart mitochondria of 6 month old mice
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homeostasis/metabolism
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• intracellular aggregates containing amyloid oligomer are seen in hearts of 6 month old mice
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muscle
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• fractional shortening and ejection fraction are slightly reduced in 6 month old mice, indicating slightly reduced cardiac function
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• mice develop cardiac disease by 6 months of age
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nervous system
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• intracellular aggregates containing amyloid oligomer are seen in hearts of 6 month old mice
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growth/size/body
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• mice exhibit cardiac hypertrophy, with increased heart weight/body weight ratios at 6 months of age
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