Tg(Myh6*/tetO-Hspb8*K141N)#Atsa
Transgene Detail

Summary

• Symbol: Tg(Myh6*/tetO-Hspb8*K141N)#Atsa
• Name: transgene insertion, Atsushi Sanbe
• MGI ID: MGI:6294491
• Transgene: Tg(Myh6*/tetO-Hspb8*K141N)#Atsa Location: unknown
• Alliance: Tg(Myh6*/tetO-Hspb8*K141N)#Atsa page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Epitope tag, Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(Myh6*/tetO-Hspb8*K141N)#Atsa expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Hspb8 (MGI:2135756)

• Mutation details: The coding region of mouse heat shock protein 8 with the lysine to asparagine missense mutation at amino acid 141 (K141N) with an N-terminal HA tag was inserted into an MHCminTetO-promotor construct. The expression of the construct was driven by a mouse alpha-myosin heavy chain promoter with 3 altered GATA sites and 2 altered thyroid-like response elements for maintaining low levels of cardiac-specific expression, under the control of a tetracycline operator. (J:197853)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:197853 Sanbe A, et al., Phenotype of cardiomyopathy in cardiac-specific heat shock protein B8 K141N transgenic mouse. J Biol Chem. 2013 Mar 29;288(13):8910-21
• All: 2 reference(s)