Analysis Tools
cardiovascular system
|
• by E11.5, a minority of homozygous embryos exhibit abnormal hearts
|
|
• by E11.5, a minority of homozygous embryos show pericardial edema
|
hemorrhage
(
J:374598
)
|
• at E10.5, a minority of homozygous embryos exhibit abnormal blood pooling
|
|
• by E11.5, most of the homozygous embryos that are alive exhibit abnormal blood pooling in the heart and in the vasculature/region of the embryo near the heart
|
craniofacial
|
• at E9.5 and E10.5, a minority of homozygous embryos exhibit abnormally shaped heads
|
embryo
|
• at E9.5, homozygous embryos are grossly normal but often slightly smaller than controls littermates
• at E10.5, most homozygous embryos are smaller but show normal germ layer patterning
• by E11.5, all are smaller than their control littermates
|
|
• at E10.5, the Tfeb+ labyrinth trophoblast layer is of normal thickness but shows increased Tfeb signal intensity, suggesting an increased density of Tfeb+ cells
• by E12.5, the Tfeb+ labyrinth layer is diminished
|
|
• at E10.5, placentas exhibit a reduced Tpbpa+ spongiotrophoblast layer
• by E12.5, the spongiotrophoblast layer is more severely reduced than at E10.5
|
|
• at E10.5-E11.5, when dissected intact, yolk sacs appear to have normal vasculature, but vessels are paler than in controls
|
|
• by E11.5, placental defects are more severe than at E10.5
• by E12.5, Gcm1+ chorioallantoic branching is impaired
|
growth/size/body
|
• at E9.5 and E10.5, a minority of homozygous embryos exhibit abnormally shaped heads
|
|
• at E9.5, homozygous embryos are grossly normal but often slightly smaller than controls littermates
• at E10.5, most homozygous embryos are smaller but show normal germ layer patterning
• by E11.5, all are smaller than their control littermates
|
homeostasis/metabolism
|
• by E11.5, a minority of homozygous embryos show pericardial edema
|
mortality/aging
|
IMPC - JAX
|
|
IMPC - JAX
|
|
• homozygous embryos are present in near Mendelian ratios at E9.5 and E10.5; approximately 1/3 of the homozygous embryos are dying at E11.5, and all are either dead or resorbing by E12.5
|
