All Phenotypes Swsap1<em1Mjn> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Swsap1^em1Mjn/Swsap1^em1Mjn	involves: C57BL/6J * CBA/J	MGI:6287687
cx2	Chek2^tm1Mak/Chek2^tm1Mak Swsap1^em1Mjn/Swsap1^em1Mjn	involves: 129P2/OlaHsd * C57BL/6J * CBA/J	MGI:6287688
cx3	Brca2^tm1Kamc/Brca2^tm1Kamc Swsap1^em1Mjn/Swsap1^em1Mjn	involves: 129P2/OlaHsd * C57BL/6J * CBA/J	MGI:6287693
cx4	Swsap1^em1Mjn/Swsap1^em1Mjn Zswim7^em1Mjn/Zswim7^em1Mjn	involves: C57BL/6J * CBA/J	MGI:6287691

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

azoospermia ( J:268570 )

• seminiferous tubules are devoid of post-meiotic germ cells

increased male germ cell apoptosis ( J:268570 )

• however, apoptosis levels at 7.5 days postpartum are normal

increased ovary apoptosis ( J:268570 )

• in some ovaries

absent ovarian follicles ( J:268570 )

• at 3 days postpartum

decreased ovary weight ( J:268570 )

• 3- to 8-fold

abnormal seminiferous tubule morphology ( J:268570 )

• reduced cellularity

decreased testis weight ( J:268570 )

• 3- to 4-fold

• however, testis weight at 7.5 days postpartum is normal

abnormal chromosomal synapsis ( J:268570 )

• at early zygonema with fewer in cells that survive to mid-pachynema

• reduced RAD51 and DMC1 focus numbers at leptonema

• crossover defects in oocytes

• however, double strand breaks form and are resected

arrest of male meiosis ( J:268570 )

• mid-pachynema

female infertility ( J:268570 )

male infertility ( J:268570 )

cellular

azoospermia ( J:268570 )

• seminiferous tubules are devoid of post-meiotic germ cells

abnormal chromosome morphology ( J:268570 )

• increased end to end fusions in spermatocytes

increased male germ cell apoptosis ( J:268570 )

• however, apoptosis levels at 7.5 days postpartum are normal

increased ovary apoptosis ( J:268570 )

• in some ovaries

endocrine/exocrine glands

increased ovary apoptosis ( J:268570 )

• in some ovaries

absent ovarian follicles ( J:268570 )

• at 3 days postpartum

decreased ovary weight ( J:268570 )

• 3- to 8-fold

abnormal seminiferous tubule morphology ( J:268570 )

• reduced cellularity

decreased testis weight ( J:268570 )

• 3- to 4-fold

• however, testis weight at 7.5 days postpartum is normal

Allelic Composition	Chek2^tm1Mak/Chek2^tm1Mak Swsap1^em1Mjn/Swsap1^em1Mjn
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chek2^tm1Mak mutation (1 available); any Chek2 mutation (53 available)
Swsap1^em1Mjn mutation (0 available); any Swsap1 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:268570 )

N	• mice exhibit normal ovary weight and follicle development

decreased oocyte number ( J:268570 )

• marginally

oligozoospermia ( J:268570 )

decreased primordial ovarian follicle number ( J:268570 )

abnormal seminiferous tubule morphology ( J:268570 )

• improved cellularity compared with Zswim7^em1Mjn homozygotes

decreased testis weight ( J:268570 )

abnormal chromosomal synapsis ( J:268570 )

• with reduced MLH1 focus numbers

impaired embryo implantation ( J:268570 )

• marginally

reduced female fertility ( J:268570 )

• reduced litter sizes

decreased litter size ( J:268570 )

• females produce reduced litters

male infertility ( J:268570 )

cellular

decreased oocyte number ( J:268570 )

• marginally

oligozoospermia ( J:268570 )

endocrine/exocrine glands

decreased primordial ovarian follicle number ( J:268570 )

abnormal seminiferous tubule morphology ( J:268570 )

• improved cellularity compared with Zswim7^em1Mjn homozygotes

decreased testis weight ( J:268570 )

Allelic Composition	Brca2^tm1Kamc/Brca2^tm1Kamc Swsap1^em1Mjn/Swsap1^em1Mjn
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca2^tm1Kamc mutation (1 available); any Brca2 mutation (132 available)
Swsap1^em1Mjn mutation (0 available); any Swsap1 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

decreased testis weight ( J:268570 )

• slight

abnormal chromosomal synapsis ( J:268570 )

• worse than in Swsap1^em1Mjn homozygotes

• delayed at early zygonema, asynapsis at early pachynema

• fewer RAD51 and DMC1 foci at leptonema and early zygonema

arrest of male meiosis ( J:268570 )

endocrine/exocrine glands

decreased testis weight ( J:268570 )

• slight

Allelic Composition	Swsap1^em1Mjn/Swsap1^em1Mjn Zswim7^em1Mjn/Zswim7^em1Mjn
Genetic Background	involves: C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Swsap1^em1Mjn mutation (0 available); any Swsap1 mutation (16 available)
Zswim7^em1Mjn mutation (0 available); any Zswim7 mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

decreased ovary weight ( J:268570 )

• 3- to 8-fold

decreased testis weight ( J:268570 )

• 3- to 4-fold

• however, testis weight at 7.5 days postpartum is normal

female infertility ( J:268570 )

male infertility ( J:268570 )

endocrine/exocrine glands

decreased ovary weight ( J:268570 )

• 3- to 8-fold

decreased testis weight ( J:268570 )

• 3- to 4-fold

• however, testis weight at 7.5 days postpartum is normal

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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