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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Zbtb1m2Btlr
mutation 2, Bruce Beutler
MGI:6286068
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Zbtb1m2Btlr/Zbtb1m2Btlr C57BL/6J-Zbtb1m2Btlr MGI:6286070


Genotype
MGI:6286070
hm1
Allelic
Composition		 Zbtb1m2Btlr/Zbtb1m2Btlr
Genetic
Background		 C57BL/6J-Zbtb1m2Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zbtb1m2Btlr mutation (0 available); any Zbtb1 mutation (113 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal CD8-positive, alpha-beta T cell differentiation ( J:272845 )
• increased CD44 expression on peripheral blood CD8+ T cells
increased central memory CD8 positive, alpha-beta T cell number ( J:272845 )
• increased frequencies of central memory CD8 T cells in CD8 T cells in the peripheral blood

hematopoietic system
abnormal CD8-positive, alpha-beta T cell differentiation ( J:272845 )
• increased CD44 expression on peripheral blood CD8+ T cells
increased central memory CD8 positive, alpha-beta T cell number ( J:272845 )
• increased frequencies of central memory CD8 T cells in CD8 T cells in the peripheral blood




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory