Phenotypes associated with this allele

• Allele Symbol: Ebf1^m6Btlr
• Allele Name: mutation 6, Bruce Beutler
• Allele ID: MGI:6286045
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ebf1^m6Btlr/Ebf1^m6Btlr	C57BL/6J-Ebf1^m6Btlr	MGI:6286047

Genotype
MGI:6286047

hm1

• Allelic Composition: Ebf1^m6Btlr/Ebf1^m6Btlr
• Genetic Background: C57BL/6J-Ebf1^m6Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal lymphocyte morphology ( J:272842 )

• reduced B to T cell ratios in the peripheral blood

decreased B cell number ( J:272842 )

• reduced frequencies of B cells, IgD+ B cells, and IgM+ B cells in the peripheral blood

decreased B-1 B cell number ( J:272842 )

• reduced frequencies of B1 cells in the peripheral blood

decreased effector memory CD4-positive, alpha-beta T cell number ( J:272842 )

• reduced frequencies of effector memory CD4 T cells in CD4 T cells in the peripheral blood

increased alpha-beta T cell number ( J:272842 )

• increased frequencies of T cells and CD44+ T cells in the peripheral blood

increased CD4-positive, alpha-beta T cell number ( J:272842 )

• increased frequencies of CD4+ T cells, CD4+ T cells in CD3+ T cells, and CD44+ CD4 T cells in the peripheral blood

• increased frequencies of naive CD4 T cells in CD4 T cells in the peripheral blood

increased CD8-positive, alpha-beta T cell number ( J:272842 )

• increased frequencies of CD8+ T cells, CD8+ T cells in CD3+ T cells, and CD44+ CD8 T cells in the peripheral blood

decreased IgD level ( J:272842 )

• expression of IgD on peripheral blood B cells was reduced

• expression of B220 on peripheral blood B cells was increased

hematopoietic system

abnormal lymphocyte morphology ( J:272842 )

• reduced B to T cell ratios in the peripheral blood

decreased B cell number ( J:272842 )

• reduced frequencies of B cells, IgD+ B cells, and IgM+ B cells in the peripheral blood

decreased B-1 B cell number ( J:272842 )

• reduced frequencies of B1 cells in the peripheral blood

decreased effector memory CD4-positive, alpha-beta T cell number ( J:272842 )

• reduced frequencies of effector memory CD4 T cells in CD4 T cells in the peripheral blood

increased alpha-beta T cell number ( J:272842 )

• increased frequencies of T cells and CD44+ T cells in the peripheral blood

increased CD4-positive, alpha-beta T cell number ( J:272842 )

• increased frequencies of CD4+ T cells, CD4+ T cells in CD3+ T cells, and CD44+ CD4 T cells in the peripheral blood

• increased frequencies of naive CD4 T cells in CD4 T cells in the peripheral blood

increased CD8-positive, alpha-beta T cell number ( J:272842 )

• increased frequencies of CD8+ T cells, CD8+ T cells in CD3+ T cells, and CD44+ CD8 T cells in the peripheral blood

decreased IgD level ( J:272842 )

• expression of IgD on peripheral blood B cells was reduced

• expression of B220 on peripheral blood B cells was increased