Phenotypes associated with this allele

• Allele Symbol: Prorp^tm1.1Afi
• Allele Name: targeted mutation 1.1, Aleksandra Filipovska
• Allele ID: MGI:6281697
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Prorp^tm1.1Afi/Prorp^tm1.1Afi Tg(Ckmm-cre)5Khn/0	involves: C57BL/6N * FVB	MGI:6282903

Genotype
MGI:6282903

cn1

• Allelic Composition: Prorp^tm1.1Afi/Prorp^tm1.1Afi; Tg(Ckmm-cre)5Khn/0
• Genetic Background: involves: C57BL/6N * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:238964 )

• mice die by 11 weeks of age

cardiovascular system

myocardium necrosis ( J:238964 )

• peaking at 11 weeks

increased heart weight ( J:238964 )

• relative to body weight, at weeks 4, 8 and 11

cardiomyopathy ( J:238964 )

• with increased heart weight, accumulation of necrotic foci in the myocardium and mitochondrial dysfunction

cellular

myocardium necrosis ( J:238964 )

• peaking at 11 weeks

abnormal mitochondrial physiology ( J:238964 )

• peaking at 11 weeks, with reduced complex I and complex IV staining in muscles

• impaired tRNA 5 end processing in heart mitochondria

abnormal mitochondrial ATP synthesis coupled electron transport ( J:238964 )

• reduced respiratory supercomplexes due to reduced biogenesis and stability

muscle

myocardium necrosis ( J:238964 )

• peaking at 11 weeks

cardiomyopathy ( J:238964 )

• with increased heart weight, accumulation of necrotic foci in the myocardium and mitochondrial dysfunction

growth/size/body

increased heart weight ( J:238964 )

• relative to body weight, at weeks 4, 8 and 11