Phenotypes associated with this allele

• Allele Symbol: Rgl1^em1(IMPC)Mbp
• Allele Name: endonuclease-mediated mutation 1, Mouse Biology Program, UC Davis
• Allele ID: MGI:6277056
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rgl1^em1(IMPC)Mbp/Rgl1^em1(IMPC)Mbp	C57BL/6N-Rgl1^em1(IMPC)Mbp/MbpMmucd	MGI:6408617
ht2	Rgl1^em1(IMPC)Mbp/Rgl1^+	C57BL/6N-Rgl1^em1(IMPC)Mbp/MbpMmucd	MGI:6408616

Genotype
MGI:6408617

hm1

• Allelic Composition: Rgl1^em1(IMPC)Mbp/Rgl1^em1(IMPC)Mbp
• Genetic Background: C57BL/6N-Rgl1^em1(IMPC)Mbp/MbpMmucd

Data Sources

IMPC Data for Rgl1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal placenta vasculature ( J:211773 )

IMPC - UCD

craniofacial

abnormal craniofacial morphology ( J:211773 )

IMPC - UCD

cleft palate ( J:211773 )

IMPC - UCD

digestive/alimentary system

cleft palate ( J:211773 )

IMPC - UCD

embryo

abnormal embryo turning ( J:211773 )

IMPC - UCD

embryonic growth retardation ( J:211773 )

IMPC - UCD

abnormal neural tube morphology ( J:211773 )

IMPC - UCD

abnormal neural tube closure ( J:211773 )

IMPC - UCD

abnormal placenta morphology ( J:211773 )

IMPC - UCD

abnormal placenta vasculature ( J:211773 )

IMPC - UCD

growth/size/body

cleft palate ( J:211773 )

IMPC - UCD

embryonic growth retardation ( J:211773 )

IMPC - UCD

homeostasis/metabolism

edema ( J:211773 )

IMPC - UCD

limbs/digits/tail

abnormal limb morphology ( J:211773 )

IMPC - UCD

polydactyly ( J:211773 )

IMPC - UCD

syndactyly ( J:211773 )

IMPC - UCD

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - UCD

nervous system

abnormal neural tube morphology ( J:211773 )

IMPC - UCD

abnormal neural tube closure ( J:211773 )

IMPC - UCD

abnormal hindbrain development ( J:211773 )

♀

IMPC - UCD

abnormal midbrain development ( J:211773 )

IMPC - UCD

vision/eye

microphthalmia ( J:211773 )

IMPC - UCD

anophthalmia ( J:211773 )

IMPC - UCD

Genotype
MGI:6408616

ht2

• Allelic Composition: Rgl1^em1(IMPC)Mbp/Rgl1⁺
• Genetic Background: C57BL/6N-Rgl1^em1(IMPC)Mbp/MbpMmucd

Data Sources

IMPC Data for Rgl1

behavior/neurological

increased startle reflex ( J:211773 )

♂

IMPC - UCD

cardiovascular system

increased heart weight ( J:211773 )

IMPC - UCD

embryo

abnormal placenta morphology ( J:211773 )

♀

IMPC - UCD

growth/size/body

increased heart weight ( J:211773 )

IMPC - UCD

enlarged kidney ( J:211773 )

♂

IMPC - UCD

enlarged spleen ( J:211773 )

IMPC - UCD

hematopoietic system

decreased mean corpuscular volume ( J:211773 )

IMPC - UCD

increased neutrophil cell number ( J:211773 )

♂

IMPC - UCD

abnormal spleen morphology ( J:211773 )

IMPC - UCD

enlarged spleen ( J:211773 )

IMPC - UCD

immune system

increased neutrophil cell number ( J:211773 )

♂

IMPC - UCD

abnormal spleen morphology ( J:211773 )

IMPC - UCD

enlarged spleen ( J:211773 )

IMPC - UCD

abnormal lymph node morphology ( J:211773 )

IMPC - UCD

enlarged lymph nodes ( J:211773 )

IMPC - UCD

liver/biliary system

abnormal liver morphology ( J:211773 )

IMPC - UCD

small liver ( J:211773 )

IMPC - UCD

nervous system

decreased prepulse inhibition ( J:211773 )

IMPC - UCD

renal/urinary system

abnormal kidney morphology ( J:211773 )

♂

IMPC - UCD

enlarged kidney ( J:211773 )

♂

IMPC - UCD

reproductive system

hydrometra ( J:211773 )

♀

IMPC - UCD