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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Grhl2em1(IMPC)Mbp
endonuclease-mediated mutation 1, Mouse Biology Program, UC Davis
MGI:6277030
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Grhl2em1(IMPC)Mbp/Grhl2em1(IMPC)Mbp C57BL/6N-Grhl2em1(IMPC)Mbp/MbpMmucd MGI:6408416
ht2
 		Grhl2em1(IMPC)Mbp/Grhl2+ C57BL/6N-Grhl2em1(IMPC)Mbp/MbpMmucd MGI:6408415


Genotype
MGI:6408416
hm1
Allelic
Composition		 Grhl2em1(IMPC)Mbp/Grhl2em1(IMPC)Mbp
Genetic
Background		 C57BL/6N-Grhl2em1(IMPC)Mbp/MbpMmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grhl2em1(IMPC)Mbp mutation (1 available); any Grhl2 mutation (42 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system

craniofacial

embryo

growth/size/body
abnormal head shape ( J:211773 )
IMPC - UCD
embryonic growth retardation ( J:211773 )
IMPC - UCD
abnormal abdominal wall morphology ( J:211773 )
IMPC - UCD

limbs/digits/tail
syndactyly ( J:211773 )
IMPC - UCD

mortality/aging

nervous system
exencephaly ( J:211773 )
IMPC - UCD

vision/eye




Genotype
MGI:6408415
ht2
Allelic
Composition		 Grhl2em1(IMPC)Mbp/Grhl2+
Genetic
Background		 C57BL/6N-Grhl2em1(IMPC)Mbp/MbpMmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grhl2em1(IMPC)Mbp mutation (1 available); any Grhl2 mutation (42 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological

cardiovascular system

embryo




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory