Phenotypes associated with this allele

• Allele Symbol: Kif6^em1Rgray
• Allele Name: endonuclease-mediated mutation 1, Ryan Gray
• Allele ID: MGI:6276219
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kif6^em1Rgray/Kif6^em1Rgray	involves: C57BL/6J	MGI:6315856

Genotype
MGI:6315856

hm1

• Allelic Composition: Kif6^em1Rgray/Kif6^em1Rgray
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:269442 )

nervous system

intracranial hemorrhage ( J:269442 )

• in older (P21-P28) mice

abnormal brain ependyma motile cilium morphology ( J:269442 )

• reduced multiciliated tufts in the lateral ventricle at P21 and more so at P28

• reduced density of ciliary axoneme within tufts

• due to defects in cilia formation rather than differentiation of ependymal cells or loss of ependymal cell cilia

hydrocephaly ( J:269442 )

• postnatal-onset, progressive in all mice

increased brain size ( J:269442 )

• in older (P21-P28) mice

dilated lateral ventricle ( J:269442 )

• with increased intracellular pressure

behavior/neurological

hunched posture ( J:269442 )

decreased locomotor activity ( J:269442 )

• in an open field

craniofacial

domed cranium ( J:269442 )

cardiovascular system

intracranial hemorrhage ( J:269442 )

• in older (P21-P28) mice

cellular

abnormal brain ependyma motile cilium morphology ( J:269442 )

• reduced multiciliated tufts in the lateral ventricle at P21 and more so at P28

• reduced density of ciliary axoneme within tufts

• due to defects in cilia formation rather than differentiation of ependymal cells or loss of ependymal cell cilia

skeleton

domed cranium ( J:269442 )