Phenotypes associated with this allele

• Allele Symbol: Tmem9^{tm1d(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1d, Wellcome Trust Sanger Institute
• Allele ID: MGI:6273211
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tmem9^tm1d(EUCOMM)Wtsi/Tmem9^tm1d(EUCOMM)Wtsi	involves: C57BL/6N	MGI:6806146
cx2	Apc^Min/Apc^+ Tmem9^tm1d(EUCOMM)Wtsi/Tmem9^tm1d(EUCOMM)Wtsi	involves: C57BL/6J * C57BL/6N	MGI:6806147
cx3	Apc^Min/Apc^+ Tmem9^tm1d(EUCOMM)Wtsi/Tmem9^+	involves: C57BL/6J * C57BL/6N	MGI:6806148

Genotype
MGI:6806146

hm1

• Allelic Composition: Tmem9^{tm1d(EUCOMM)Wtsi}/Tmem9^{tm1d(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:268691 )

• mice are viable and overtly normal and show no detectable defects in intestinal epithelium cell differentiation

Genotype
MGI:6806147

cx2

• Allelic Composition: Apc^Min/Apc⁺; Tmem9^{tm1d(EUCOMM)Wtsi}/Tmem9^{tm1d(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6J * C57BL/6N

mortality/aging

extended life span ( J:268691 )

• mice exhibit a median survival of 323 days versus 124 days in Apc^Min heterozygotes

neoplasm

decreased intestinal adenoma incidence ( J:268691 )

• at 3 months of age, the number of intestinal adenomas is significantly lower than that in Apc^Min heterozygotes

abnormal tumor pathology ( J:268691 )

• at 3 months of age, intestinal adenomas show downregulation of Wnt/beta-catenin target genes, reduced cell proliferation, and a decreased number of nuclear beta-catenin-positive cells relative to those in Apc^Min heterozygotes

• however, no differences in apoptosis or epithelial-mesenchymal transition are observed

decreased tumor cell proliferation ( J:268691 )

• at 3 months of age, intestinal adenomas show reduced cell proliferation relative to those in Apc^Min heterozygotes

decreased tumor growth/size ( J:268691 )

• at 3 months of age, the size of intestinal adenomas is slightly smaller than that in Apc^Min heterozygotes

digestive/alimentary system

decreased intestinal adenoma incidence ( J:268691 )

• at 3 months of age, the number of intestinal adenomas is significantly lower than that in Apc^Min heterozygotes

Genotype
MGI:6806148

cx3

• Allelic Composition: Apc^Min/Apc⁺; Tmem9^{tm1d(EUCOMM)Wtsi}/Tmem9⁺
• Genetic Background: involves: C57BL/6J * C57BL/6N

mortality/aging

extended life span ( J:268691 )

• mice exhibit a median survival of 199 days versus 124 days in Apc^Min heterozygotes

neoplasm

decreased intestinal adenoma incidence ( J:268691 )

• at 3 months of age, the number of intestinal adenomas is significantly lower than that in Apc^Min heterozygotes

• however, tumor size is not significantly changed despite a reduction in cell proliferation

digestive/alimentary system

decreased intestinal adenoma incidence ( J:268691 )

• at 3 months of age, the number of intestinal adenomas is significantly lower than that in Apc^Min heterozygotes

• however, tumor size is not significantly changed despite a reduction in cell proliferation